SCHEMBL7074348

SCHEMBL7074348

O=C(NO)c1ccccc1CS(=O)(=O)N1CCC(Oc2ccc(Cl)cc2)CC1

nearest known ligand 0.53

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MMP13 P45452 7/20 0.53
MMP2 P08253 5/20 0.53
LMNA P02545 1/20 0.46
MMP12 P39900 1/20 0.46
EPHX2 P34913 3/20 0.43
MAPT P10636 1/20 0.43
TSHR P16473 1/20 0.43
MMP1 P03956 2/20 0.42
HRH1 P35367 1/20 0.42
CCR3 P51677 1/20 0.42
KCNH2 Q12809 1/20 0.42
ACLY P53396 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2J2 P51589 1/20 0.42
USP5 P45974 1/20 0.42
MMP9 P14780 1/20 0.41
ADAM17 P78536 1/20 0.41
CHRM2 P08172 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7072144 0.89 HRH1 (0.49) MMP13LMNAMMP12EPHX2MAPT
SCHEMBL7079580 0.88 MMP13 (0.48) MMP13MMP2LMNAMMP12EPHX2
SCHEMBL7074335 0.82 LMNA (0.61) LMNAMAPTTSHR
SCHEMBL7074343 0.82 MMP2 (0.76) MMP13MMP2MAPTHRH1CCR3
SCHEMBL7077470 0.80 BCL2 (0.46) LMNAMAPT
SCHEMBL7076370 0.76 MMP2 (0.53) MMP13MMP2MMP12EPHX2MMP1
SCHEMBL7076681 0.72 ACLY (0.60) MMP13MMP2EPHX2MAPTHRH1
SCHEMBL7072306 0.72 ACLY (0.57) MMP13MMP2MMP12EPHX2HRH1
SCHEMBL7076424 0.72 MMP2 (0.61) MMP13MMP2LMNAMAPTACLY
SCHEMBL7076658 0.71 MAPT (0.63) LMNAMAPTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2003525203-A 2003-08-26 JP claimed
US-20030022893-A1 Hydroxamic and carboxylic acid derivatives BAXTER ANDREW DOUGLAS (GB) 2003-01-30 US claimed
US-6465468-B1 SUCH AS N-HYDROXY-2-(4-(4-CHLOROPHENYL)PIPERAZINE-1-SULFONYL)BENZAMIDE; INHIBITORS OF MATRIX METALLOPROTEINASE, ADAM OR ADAMTS ENZYMES; TREATMENT OF DEGENERATIVE DISEASES AND CERTAIN CANCERS DARWIN DISCOVERY LIMITED (GB) 2002-10-15 US claimed
EP-1163213-A1 HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES Darwin Discovery Limited (GB) 2001-12-19 EP claimed
WO-2000056704-A1 HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES DARWIN DISCOVERY LIMITED (GB) 2000-09-28 WO claimed
US-20030022893-A1 Hydroxamic and carboxylic acid derivatives BAXTER ANDREW DOUGLAS (GB) 2003-01-30 US disclosed
US-6465468-B1 SUCH AS N-HYDROXY-2-(4-(4-CHLOROPHENYL)PIPERAZINE-1-SULFONYL)BENZAMIDE; INHIBITORS OF MATRIX METALLOPROTEINASE, ADAM OR ADAMTS ENZYMES; TREATMENT OF DEGENERATIVE DISEASES AND CERTAIN CANCERS DARWIN DISCOVERY LIMITED (GB) 2002-10-15 US disclosed