Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 9/20 | 0.41 |
| ▸ | F10 | P00742 | 9/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 4/20 | 0.36 |
| ▸ | MMP1 | P03956 | 3/20 | 0.36 |
| ▸ | MMP3 | P08254 | 3/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP8 | P22894 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7077971 | 0.83 | MMP13 (0.44) | MMP2MMP1MMP9ALDH1A1PDE4A | |
| SCHEMBL7077874 | 0.83 | F2 (0.46) | F2F10PRSS1MMP2MMP1 | |
| SCHEMBL8359412 | 0.81 | MMP13 (0.42) | MMP2MMP1MMP3ALDH1A1PDE4A | |
| SCHEMBL7079158 | 0.81 | SMN1; SMN2 (0.43) | F2F10PRSS1KMT2AALDH1A1 | |
| SCHEMBL7073376 | 0.74 | ALDH1A1 (0.46) | F2F10PRSS1KMT2AMMP2 | |
| SCHEMBL7073328 | 0.74 | ALDH1A1 (0.40) | F2F10PRSS1KMT2AALDH1A1 | |
| SCHEMBL7074301 | 0.74 | AOC3 (0.39) | F2F10PRSS1KMT2AALDH1A1 | |
| SCHEMBL7079112 | 0.74 | F10 (0.41) | F2F10PRSS1KMT2AMMP2 | |
| SCHEMBL7079124 | 0.73 | ALDH1A1 (0.45) | KMT2AMMP2MMP3ALDH1A1PDE4A | |
| SCHEMBL7079059 | 0.73 | ALDH1A1 (0.45) | KMT2AMMP2MMP3ALDH1A1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003059872-A1 | AVB3 AND AVB5 INTEGRIN ANTAGONISTS AND METHODS OF TREATING DISEASES OR CONDITIONS ASSOCIATED WITH AVB3 AND AVB5 INTEGRINS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-07-24 | — | — | WO | disclosed |