Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 8/20 | 0.57 |
| ▸ | CA9 | Q16790 | 7/20 | 0.57 |
| ▸ | CA1 | P00915 | 6/20 | 0.57 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | CA5A | P35218 | 2/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | AGXT | P21549 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10708908 | 0.96 | CA2 (0.57) | CA2CA9CA1CA12CA5A | |
| SCHEMBL2932534 | 0.96 | CA2 (0.57) | CA2CA9CA1CA12CA5A | |
| SCHEMBL10709450 | 0.96 | CA2 (0.57) | CA2CA9CA1CA12CA5A | |
| SCHEMBL9861698 | 0.85 | IDO1 (0.47) | CA2CA9CA1CA12TSHR | |
| SCHEMBL9860960 | 0.85 | IDO1 (0.47) | CA2CA9CA1CA12TSHR | |
| SCHEMBL10855031 | 0.85 | IDO1 (0.47) | CA2CA9CA1CA12TSHR | |
| Methacrylic Acid SCHEMBL17330300 | 0.84 | ALDH1A1 (0.42) | CA2CA9CA1CA12ALDH1A1 | |
| Methacrylic Acid SCHEMBL17330305 | 0.84 | ALDH1A1 (0.42) | CA2CA9CA1CA12ALDH1A1 | |
| Potassium Ion SCHEMBL12483362 | 0.83 | CA2 (0.61) | CA2CA9CA1CA12CA5A | |
| SCHEMBL28246768 | 0.81 | CA2 (0.63) | CA2CA9CA1CA12CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998544-B1 | GREASE COMPOSITION FOR A CONSTANT VELOCITY JOINT | SHELL INT RESEARCH (NL) | 2003-07-02 | — | — | EP | disclosed |
| EP-0998544-A1 | GREASE COMPOSITION FOR A CONSTANT VELOCITY JOINT | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 2000-05-10 | — | — | EP | disclosed |
| WO-1999005240-A1 | GREASE COMPOSITION FOR A CONSTANT VELOCITY JOINT | SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) | 1999-02-04 | — | — | WO | disclosed |
| EP-0420626-B1 | Lubricant compositions | DESILUBE TECH INC (US) | 1995-06-21 | — | — | EP | disclosed |
| EP-0420626-A1 | Lubricant compositions | DESILUBE TECHNOLOGY, INC. (US) | 1991-04-03 | — | — | EP | disclosed |
| US-4923625-A | METAL THIOSULFATE, METAL PHOSPHATE | DESILUBE TECHNOLOGY, INC. (US) | 1990-05-08 | — | — | US | disclosed |