Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terevalefim. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terevalefim SCHEMBL7169262 | 0.86 | ELANE (0.42) | ELANEALDH1A1KMT2AMAPTSMN1; SMN2 | |
| Terevalefim SCHEMBL7169259 | 0.86 | ELANE (0.42) | ELANEALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL1224671 | 0.72 | RAB9A (0.54) | ALDH1A1KMT2AMAPTSMN1; SMN2RAB9A | |
| SCHEMBL6348254 | 0.68 | ENPP3 (0.62) | ELANEALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL1225252 | 0.61 | KMT2A (0.45) | ELANEALDH1A1KMT2AMAPTRAB9A | |
| SCHEMBL1225255 | 0.61 | KMT2A (0.45) | ELANEALDH1A1KMT2AMAPTRAB9A | |
| SCHEMBL1224414 | 0.60 | RAB9A (0.54) | ELANEALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL1505308 | 0.60 | NPC1 (0.53) | ALDH1A1MAPTSMN1; SMN2RAB9ANPC1 | |
| Terevalefim SCHEMBL1225336 | 0.58 | KMT2A (0.49) | ALDH1A1KMT2AMAPTSMN1; SMN2RAB9A | |
| Terevalefim SCHEMBL1225335 | 0.58 | KMT2A (0.49) | ALDH1A1KMT2AMAPTSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6589997-B2 | 1-Phenylprop-2-en-1-one derivatives as wound healing, anticarcinogenic, antiarthritic, antitumor, antiproliferative, antiinflammatory or antimetastasis agents | NORTH SHORE-LONG ISLAND JEWISH HEALTH SYSTEM | 2003-07-08 | — | — | US | disclosed |
| US-20030045559-A1 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | NORTH SHORE-LONG ISLAND JEWISH HEALTH SYSTEM | 2003-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045559-A1 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | HGF, HDGF, MET | ELANE 1810/4885ALDH1A1 510/4885KMT2A 4257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.