Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 8/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.45 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7130131 | 0.86 | ITGB3 (0.46) | KDM4EALDH1A1SMN1; SMN2HTT | |
| SCHEMBL7135413 | 0.84 | GRM4 (0.53) | GRM4GAAKDM4ELMNASMN1; SMN2 | |
| SCHEMBL7080988 | 0.81 | ITGB3 (0.44) | LMNAALDH1A1SMN1; SMN2HTTMEN1 | |
| SCHEMBL7162980 | 0.80 | ITGB3 (0.36) | LMNASMN1; SMN2HTT | |
| SCHEMBL10279296 | 0.79 | CA12 (0.40) | — | |
| SCHEMBL7079926 | 0.77 | MAOA (0.48) | ALDH1A1ATM | |
| SCHEMBL7079307 | 0.76 | BDKRB1 (0.34) | ALDH1A1ATM | |
| SCHEMBL7076145 | 0.76 | BDKRB1 (0.34) | ALDH1A1ATM | |
| SCHEMBL7075687 | 0.76 | BDKRB1 (0.34) | ALDH1A1ATM | |
| SCHEMBL7131622 | 0.74 | MMP2 (0.33) | GAALMNAALDH1A1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003059872-A1 | AVB3 AND AVB5 INTEGRIN ANTAGONISTS AND METHODS OF TREATING DISEASES OR CONDITIONS ASSOCIATED WITH AVB3 AND AVB5 INTEGRINS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-07-24 | — | — | WO | disclosed |