Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 4/20 | 0.44 |
| ▸ | ITGAV | P06756 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7078388 | 0.87 | NAMPT (0.44) | ITGB3ITGAVCA2CA12CA1 | |
| SCHEMBL7078041 | 0.83 | RORC (0.47) | RORCLMNAALDH1A1CYP2C9ATM | |
| SCHEMBL7080966 | 0.81 | KDR (0.47) | MEN1KMT2ANPC1RAB9ALMNA | |
| SCHEMBL10279296 | 0.81 | CA12 (0.40) | CA2CA12CA1CA9RORC | |
| SCHEMBL7130423 | 0.81 | RORC (0.44) | NPC1MAPTRAB9ARORCLMNA | |
| SCHEMBL7078136 | 0.81 | MMP2 (0.58) | CA2CA12CA1CA9 | |
| SCHEMBL8360105 | 0.80 | RORC (0.43) | CA2CA12CA1CA9RORC | |
| SCHEMBL7079926 | 0.79 | MAOA (0.48) | CA2CA1CA9ALDH1A1ATM | |
| SCHEMBL7130131 | 0.79 | ITGB3 (0.46) | ITGB3ITGAVMAPTALDH1A1HTT | |
| SCHEMBL7130143 | 0.77 | ALDH1A1 (0.37) | CA2CA12CA1CA9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003059872-A1 | AVB3 AND AVB5 INTEGRIN ANTAGONISTS AND METHODS OF TREATING DISEASES OR CONDITIONS ASSOCIATED WITH AVB3 AND AVB5 INTEGRINS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-07-24 | — | — | WO | disclosed |