Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 3/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.39 |
| ▸ | HTR1D | P28221 | 3/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7091958 | 0.87 | CYP1A2 (0.46) | HTR6HTR2ASCN9ALTA4HPLA2G2A | |
| SCHEMBL7084434 | 0.78 | LTA4H (0.50) | HTR6HTR2ALTA4HPLA2G2AHTR1D | |
| SCHEMBL7089721 | 0.77 | THRA (0.45) | HTR2ALTA4HPLA2G2ATHRATHRB | |
| SCHEMBL7088062 | 0.77 | LTA4H (0.48) | HTR2ALTA4HPLA2G2AHTR1DMEN1 | |
| SCHEMBL7088921 | 0.77 | THRA (0.44) | THRATHRBMEN1KMT2AFAAH | |
| SCHEMBL7090515 | 0.76 | THRA (0.56) | HTR2ALTA4HPLA2G2ATHRATHRB | |
| SCHEMBL7082793 | 0.76 | LTA4H (0.48) | HTR2ALTA4HPLA2G2AHTR1DMEN1 | |
| SCHEMBL7088534 | 0.75 | HTR1B (0.48) | HTR2ALTA4HPLA2G2AHTR1DMEN1 | |
| SCHEMBL7087730 | 0.75 | THRA (0.48) | HTR2ALTA4HPLA2G2ATHRATHRB | |
| SCHEMBL7085718 | 0.73 | HTR1D (0.50) | HTR6HTR2ALTA4HPLA2G2AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268422-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | Bayer Aktiengesellschaft (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070687-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-27 | — | — | WO | disclosed |