Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 4/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7085718 | 0.87 | HTR1D (0.50) | HTR1DHTR6HRH3HTR2AMEN1 | |
| SCHEMBL7082736 | 0.87 | HTR6 (0.41) | HTR1DHTR6HTR2AMEN1KMT2A | |
| SCHEMBL7084434 | 0.81 | LTA4H (0.50) | CYP1A2CYP2D6CYP2C9CYP2C19HTR1D | |
| SCHEMBL7088062 | 0.79 | LTA4H (0.48) | CYP1A2CYP2D6CYP2C9CYP2C19HTR1D | |
| SCHEMBL7082793 | 0.78 | LTA4H (0.48) | CYP1A2CYP2D6CYP2C9CYP2C19HTR1D | |
| SCHEMBL7088534 | 0.78 | HTR1B (0.48) | CYP1A2CYP2D6CYP2C9CYP2C19HTR1D | |
| SCHEMBL7087730 | 0.76 | THRA (0.48) | HTR2AMEN1KMT2AMAPTLTA4H | |
| SCHEMBL7089721 | 0.75 | THRA (0.45) | HTR2AMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7082617 | 0.74 | LTA4H (0.43) | HTR1DHTR6HTR2AMEN1KMT2A | |
| SCHEMBL7090515 | 0.72 | THRA (0.56) | HTR2ALTA4HPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268422-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | Bayer Aktiengesellschaft (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070687-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-27 | — | — | WO | disclosed |