Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.32 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6959029 | 0.94 | IDO1 (0.35) | GSK3BIDO1ALDH1A1TDP1KDM4E | |
| SCHEMBL6966489 | 0.91 | TLR8 (0.35) | TLR8GSK3BALDH1A1TDP1TLR7 | |
| SCHEMBL7084751 | 0.91 | ALDH1A1 (0.38) | TLR8ALDH1A1TDP1KDM4ELMNA | |
| SCHEMBL7079909 | 0.90 | IDO1 (0.36) | IDO1ALDH1A1TDP1KDM4EHPGD | |
| SCHEMBL7085890 | 0.90 | GSK3B (0.34) | GSK3BALDH1A1TDP1LMNATLR7 | |
| SCHEMBL7086620 | 0.89 | GSK3B (0.40) | GSK3BALDH1A1TDP1KDM4ETLR7 | |
| SCHEMBL6974232 | 0.88 | IDO1 (0.35) | GSK3BIDO1ALDH1A1TDP1KDM4E | |
| SCHEMBL6971946 | 0.87 | TLR8 (0.40) | TLR8ALDH1A1TDP1KDM4ELMNA | |
| SCHEMBL6967782 | 0.87 | LMNA (0.39) | IDO1ALDH1A1TDP1KDM4ELMNA | |
| SCHEMBL6967360 | 0.86 | IDO1 (0.36) | IDO1ALDH1A1TDP1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |