Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.31 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7080253 | 0.84 | HDAC4 (0.32) | — | |
| SCHEMBL7085592 | 0.81 | HDAC4 (0.31) | — | |
| SCHEMBL7079652 | 0.79 | P2RX7 (0.32) | P2RX7 | |
| SCHEMBL7083692 | 0.75 | SIGMAR1 (0.39) | P2RX7SIGMAR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL6684047 | 0.69 | SIGMAR1 (0.33) | P2RX7SIGMAR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL9721521 | 0.67 | HSD11B1 (0.42) | P2RX7SIGMAR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL7082454 | 0.66 | — | — | |
| SCHEMBL6551864 | 0.65 | SLC22A2 (0.30) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1939655 | 0.65 | SLC22A2 (0.30) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7079601 | 0.64 | HSP90AA1 (0.33) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003064372-A1 | 2-ADAMANTYLALKYLAMINES AND THEIR USE IN THE TREATMENT OF CONDITIONS GENERALLY ASSOCIATED WITH ABNORMALITIES IN GLUTAMATERGIC TRANSMISSION | VERNALIS RESEARCH LIMITED (GB) | 2003-08-07 | — | — | WO | disclosed |