Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | IL1RN | P18510 | 1/20 | 0.48 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.48 |
| ▸ | ACP1 | P24666 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3053462 | 0.83 | HDAC2 (0.54) | KEAP1CA1CA2CA12CA9 | |
| SCHEMBL3802959 | 0.83 | CA1 (0.52) | KEAP1CA1CA2IL1RNERAP1 | |
| SCHEMBL19971753 | 0.82 | ACP1 (0.67) | CA1CA2ACP1CA12CA9 | |
| SCHEMBL3204466 | 0.82 | POLB (0.52) | CA1CA2CA12CA9KMT2A | |
| SCHEMBL59151 | 0.81 | KEAP1 (0.64) | KEAP1CA1CA2IL1RNERAP1 | |
| SCHEMBL11583151 | 0.80 | KEAP1 (0.44) | KEAP1CA1CA2IL1RNERAP1 | |
| SCHEMBL14409297 | 0.79 | TGM2 (0.56) | KEAP1CA1CA2IL1RNERAP1 | |
| SCHEMBL9302939 | 0.79 | KEAP1 (0.42) | KEAP1CA1CA2IL1RNERAP1 | |
| SCHEMBL23141160 | 0.79 | KEAP1 (0.61) | KEAP1CA1CA2IL1RNERAP1 | |
| SCHEMBL27640456 | 0.78 | TMPRSS6 (0.51) | KEAP1CA1CA2IL1RNERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0592439-B1 | AMINOSULFONYL CARBAMATES | WARNER LAMBERT CO (US) | 2003-07-30 | — | — | EP | claimed |
| EP-2970116-A1 | ARYL SULFAMIDE AND SULFAMATE DERIVATIVES AS RORc MODULATORS | F. Hoffmann-La Roche AG (CH) | 2016-01-20 | — | — | EP | disclosed |
| US-8912219-B2 | Aryl sulfamide and sulfamate derivatives as RORc modulators | GENENTECH, INC. (US) | 2014-12-16 | — | — | US | disclosed |
| WO-2014140059-A1 | ARYL SULFAMIDE AND SULFAMATE DERIVATIVES AS RORc MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-09-18 | — | — | WO | disclosed |
| US-20140275032-A1 | ARYL SULFAMIDE AND SULFAMATE DERIVATIVES AS RORc MODULATORS | GENENTECH, INC. (US) | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275032-A1 | ARYL SULFAMIDE AND SULFAMATE DERIVATIVES AS RORc MODULATORS | RORA, RORC, RORB | KEAP1 2586/4885CA1 2133/4885CA2 2079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.