Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966257 | 0.95 | TLR7 (0.35) | TLR7KDM4EALDH1A1PLA2G2APTGDR2 | |
| SCHEMBL6974739 | 0.91 | PLA2G2A (0.35) | TLR7LMNAKDM4EALDH1A1PLA2G2A | |
| SCHEMBL7087646 | 0.91 | S1PR3 (0.37) | TLR7PLA2G2AS1PR3 | |
| SCHEMBL6961282 | 0.91 | SMN1; SMN2 (0.35) | TLR7ALDH1A1PLA2G2ATP53S1PR3 | |
| SCHEMBL6972895 | 0.91 | S1PR3 (0.37) | TLR7LMNAKDM4EALDH1A1PLA2G2A | |
| SCHEMBL6972647 | 0.91 | ADRA1D (0.34) | TLR7LMNAKDM4EALDH1A1PLA2G2A | |
| SCHEMBL6967466 | 0.90 | ALDH1A1 (0.33) | TLR7LMNAKDM4EALDH1A1PLA2G2A | |
| SCHEMBL6967024 | 0.89 | ALDH1A1 (0.35) | TLR7LMNAKDM4EALDH1A1PLA2G2A | |
| SCHEMBL6974911 | 0.88 | CFTR (0.38) | LMNAKDM4EALDH1A1POLBS1PR3 | |
| SCHEMBL7082248 | 0.86 | LMNA (0.40) | TLR7LMNAPPARGENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |