Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 14/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6972492 | 0.95 | S1PR3 (0.38) | S1PR3OPRM1PLA2G2ALMNAKDM4E | |
| SCHEMBL7087646 | 0.94 | S1PR3 (0.37) | S1PR3TLR7HTR7OPRM1PLA2G2A | |
| SCHEMBL6961563 | 0.91 | S1PR3 (0.37) | S1PR3TLR7PLA2G2A | |
| SCHEMBL6974739 | 0.91 | PLA2G2A (0.35) | S1PR3TLR7PLA2G2ALMNAKDM4E | |
| SCHEMBL7086919 | 0.91 | TLR7 (0.37) | S1PR3TLR7PLA2G2ALMNAKDM4E | |
| SCHEMBL6972647 | 0.90 | ADRA1D (0.34) | S1PR3TLR7PLA2G2ALMNAKDM4E | |
| SCHEMBL7084640 | 0.90 | S1PR3 (0.39) | S1PR3TLR7OPRM1PLA2G2ALMNA | |
| SCHEMBL7078426 | 0.89 | S1PR3 (0.38) | S1PR3OPRM1PLA2G2A | |
| SCHEMBL6971875 | 0.88 | LMNA (0.41) | TLR7LMNA | |
| SCHEMBL6972231 | 0.87 | NPC1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |