Sugi Predict

Sugi Predict / Compounds / SCHEMBL7087951

SCHEMBL7087951

SCHEMBL7087951

C=C(SC)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 4/20 0.45
▸ MEN1 O00255 3/20 0.45
▸ LMNA P02545 3/20 0.40
▸ MAPT P10636 3/20 0.40
▸ XBP1 P17861 2/20 0.40
▸ NPSR1 Q6W5P4 2/20 0.40
▸ ATM Q13315 1/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ ALDH1A1 P00352 4/20 0.38
▸ KDM4E B2RXH2 1/20 0.38
▸ GAA P10253 1/20 0.38
▸ NFKB1 P19838 1/20 0.38
▸ OPRK1 P41145 1/20 0.38
▸ NFKB2 Q00653 1/20 0.38
▸ RELA Q04206 1/20 0.38
▸ MAPK1 P28482 1/20 0.38
▸ RAB9A P51151 1/20 0.38
▸ CES2 O00748 3/20 0.38
▸ CES1 P23141 3/20 0.38
▸ TSHR P16473 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL658242 0.78 CES1 (0.41) KMT2AMEN1LMNAMAPTXBP1
SCHEMBL3956653 0.78 KMT2A (0.48) KMT2AMEN1LMNAMAPTXBP1
SCHEMBL775847 0.78 CES1 (0.41) KMT2AMEN1LMNAMAPTXBP1
SCHEMBL21697627 0.75 CES2 (0.39) KMT2AMEN1LMNAMAPTXBP1
SCHEMBL775849 0.74 CA12 (0.40) KMT2AMEN1LMNAMAPTXBP1
SCHEMBL22593583 0.74 MAOA (0.41) KMT2AMEN1LMNAMAPTXBP1
SCHEMBL19677301 0.73 HDAC3 (0.46) KMT2AMEN1LMNAMAPTXBP1
SCHEMBL5344409 0.72 KMT2A (0.48) KMT2AMEN1LMNAMAPTXBP1
SCHEMBL10947200 0.72 LMNA (0.37) KMT2AMEN1LMNAMAPTXBP1
SCHEMBL12900913 0.72 MAPT (0.40) KMT2AMEN1LMNAMAPTNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108530453-A One kind 2（3）To methylthio phenyl vinyl-benzofuran quinoline and its preparation method and application 中山大学 2018-09-14 — — CN claimed
US-11753387-B2 Compounds for optically active devices Johnson & Johnson Surgical Vision, Inc. (US) 2023-09-12 — — US disclosed
US-20230273455-A1 OPTICALLY ACTIVE DEVICES JOHNSON & JOHNSON SURGICAL VISION INC (US) 2023-08-31 — — US disclosed
US-20230273455-A1 OPTICALLY ACTIVE DEVICES JOHNSON & JOHNSON SURGICAL VISION INC (US) 2023-08-31 — — US disclosed
US-20230273456-A1 OPTICALLY ACTIVE DEVICES JOHNSON & JOHNSON SURGICAL VISION INC (US) 2023-08-31 — — US disclosed
US-20230273456-A1 OPTICALLY ACTIVE DEVICES JOHNSON & JOHNSON SURGICAL VISION INC (US) 2023-08-31 — — US disclosed
US-11702396-B2 Hydrophobic compounds for optically active devices Johnson & Johnson Surgical Vision, Inc. (US) 2023-07-18 — — US disclosed
US-11702396-B2 Hydrophobic compounds for optically active devices Johnson & Johnson Surgical Vision, Inc. (US) 2023-07-18 — — US disclosed
US-20230203214-A1 AZACOUMARIN AND AZATHIOCOUMARIN DERIVATIVES FOR USE IN OPTICALLY ACTIVE DEVICES AMO Ireland (IE) 2023-06-29 — — US disclosed
US-20230203214-A1 AZACOUMARIN AND AZATHIOCOUMARIN DERIVATIVES FOR USE IN OPTICALLY ACTIVE DEVICES AMO Ireland (IE) 2023-06-29 — — US disclosed
US-20200062739-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2020-02-27 — — US disclosed
US-20200055833-A1 HYDROPHOBIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2020-02-20 — — US disclosed
CN-110105495-A Rare earth styrene derivative/isoprene/butadiene ternary rubber and preparation method thereof 大连理工大学 2019-08-09 — — CN disclosed
CN-106905460-B A kind of self-healing polymers material and preparation method thereof 东南大学 2019-04-30 — — CN disclosed
CN-108530453-A One kind 2（3）To methylthio phenyl vinyl-benzofuran quinoline and its preparation method and application 中山大学 2018-09-14 — — CN disclosed
CN-108530453-A One kind 2（3）To methylthio phenyl vinyl-benzofuran quinoline and its preparation method and application 中山大学 2018-09-14 — — CN disclosed
CN-106905460-A A kind of self-healing polymers material and preparation method thereof 东南大学 2017-06-30 — — CN disclosed
EP-1052661-B1 Metal complex dye for a photoelectrochemical cell FUJIFILM CORP (JP) 2011-11-02 — — EP disclosed
EP-1363635-A1 SUBSTITUTED 8-ARYLQUINOLINE PHOSPHODIESTERASE-4 INHIBITORS Merck & Co., Inc. (US) 2003-11-26 — — EP disclosed
WO-2002069970-A1 SUBSTITUTED 8-ARYLQUINOLINE PHOSPHODIESTERASE-4 INHIBITORS MERCK & CO., INC. (US) 2002-09-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200055833-A1 HYDROPHOBIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES UACA, CRYZ, TRPA1 KMT2A 4264/4885MEN1 3033/4885LMNA 2186/4885
US-11702396-B2 Hydrophobic compounds for optically active devices UACA, CRYZ, TRPA1 KMT2A 4264/4885MEN1 3033/4885LMNA 2186/4885
US-20230273456-A1 OPTICALLY ACTIVE DEVICES PDE6C, PDE6D, PDE6A KMT2A 3838/4885MEN1 3047/4885LMNA 1560/4885
US-20230273455-A1 OPTICALLY ACTIVE DEVICES PDE6C, PDE6A, PDE6D KMT2A 4011/4885MEN1 3042/4885LMNA 1559/4885
US-11753387-B2 Compounds for optically active devices PDE6C, PDE6A, PDE6D KMT2A 4130/4885MEN1 1816/4885LMNA 3299/4885
US-20200062739-A1 COMPOUNDS FOR OPTICALLY ACTIVE DEVICES PDE6C, PDE6A, PDE6D KMT2A 4130/4885MEN1 1816/4885LMNA 3299/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.