Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 4/20 | 0.39 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RARG | P13631 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5382845 | 0.82 | PARP1 (0.40) | L3MBTL1RORCMAPTLMNAMEN1 | |
| SCHEMBL5373289 | 0.72 | KMT2A (0.56) | L3MBTL1MAPTMEN1KMT2AACHE | |
| SCHEMBL5377919 | 0.69 | PTGER1 (0.47) | L3MBTL1RORCELANEMAPTLMNA | |
| SCHEMBL8441836 | 0.69 | MAPT (0.59) | L3MBTL1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL5378014 | 0.69 | L3MBTL1 (0.58) | L3MBTL1ELANEMAPTLMNAMEN1 | |
| SCHEMBL5372323 | 0.67 | LMNA (0.53) | ELANEF2PLAUCTRB1MAPT | |
| SCHEMBL5381752 | 0.67 | RORC (0.49) | RORCRARGPPARG | |
| SCHEMBL9171787 | 0.66 | ALDH1A1 (0.54) | MAPTLMNAALDH1A1CES2CES1 | |
| SCHEMBL99918 | 0.66 | CASP6 (0.64) | MAPTLMNAALDH1A1 | |
| SCHEMBL5377771 | 0.65 | PRMT1 (0.46) | ELANEMAPTLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313711-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002010137-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2002-02-07 | — | — | WO | disclosed |