SCHEMBL7091918

SCHEMBL7091918

CC(=O)C(C)=Nc1cccc(C)c1C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.39
ATM Q13315 1/20 0.39
ALDH1A1 P00352 5/20 0.37
SIGMAR1 Q99720 2/20 0.36
CYP3A4 P08684 2/20 0.35
HDAC3 O15379 1/20 0.35
HDAC4 P56524 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC7 Q8WUI4 1/20 0.35
HDAC2 Q92769 1/20 0.35
HDAC10 Q969S8 1/20 0.35
HDAC11 Q96DB2 1/20 0.35
HDAC8 Q9BY41 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
HDAC9 Q9UKV0 1/20 0.35
HDAC5 Q9UQL6 1/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
NPC1 O15118 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2349476 0.88 TRPA1 (0.44) TRPA1ATMALDH1A1SIGMAR1CYP3A4
SCHEMBL7089231 0.84 SIGMAR1 (0.50) ALDH1A1SIGMAR1MEN1KMT2ASMN1; SMN2
SCHEMBL7089233 0.84 SIGMAR1 (0.50) ALDH1A1SIGMAR1MEN1KMT2ASMN1; SMN2
SCHEMBL20408303 0.84 SIGMAR1 (0.50) ALDH1A1SIGMAR1MEN1KMT2ASMN1; SMN2
SCHEMBL13459536 0.79 TRPA1 (0.44) TRPA1ATMALDH1A1SIGMAR1CYP3A4
SCHEMBL7093096 0.78 GRIN2D (0.44) TRPA1ATMALDH1A1SIGMAR1HDAC3
SCHEMBL22100675 0.78 NOS1 (0.45) TRPA1ATMALDH1A1SIGMAR1MEN1
SCHEMBL13459520 0.76 TRPA1 (0.41) TRPA1ATMALDH1A1SIGMAR1CYP3A4
SCHEMBL18379075 0.76 TRPA1 (0.41) TRPA1ATMALDH1A1SIGMAR1CYP3A4
SCHEMBL8065124 0.73 THRB (0.42) TRPA1ALDH1A1CYP3A4MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003084662-A2 COVALENTLY FIXED LIGAND SYSTEMS, NON-METALLOCENE SYSTEMS AND CATALYST SYSTEMS, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF FOR POLYMERIZING OLEFINS CELANESE VENTURES GMBH (DE) 2003-10-16 WO disclosed