Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD5 | Q86SK9 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7096791 | 0.77 | ADORA2A (0.48) | SCD5L3MBTL1ADORA2AADORA1ADORA2B | |
| SCHEMBL7093504 | 0.77 | KCNH2 (0.49) | ALDH1A1HPGDL3MBTL1POLBMEN1 | |
| SCHEMBL7004006 | 0.76 | L3MBTL1 (0.64) | SCD5KDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL6693877 | 0.75 | ALDH1A1 (0.56) | SCD5KDM4EALDH1A1MAPTL3MBTL1 | |
| SCHEMBL7092539 | 0.75 | ADORA2A (0.50) | SCD5ALDH1A1MAPTL3MBTL1POLB | |
| SCHEMBL27824744 | 0.75 | MAPT (0.51) | ALDH1A1MAPTHPGDL3MBTL1POLB | |
| SCHEMBL7097845 | 0.72 | ADORA2A (0.43) | SCD5KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL6691423 | 0.69 | ADORA2A (0.48) | SCD5KDM4EALDH1A1MAPTL3MBTL1 | |
| SCHEMBL7094550 | 0.67 | DAO (0.39) | SCD5ALDH1A1L3MBTL1POLBADORA2A | |
| SCHEMBL7098488 | 0.67 | L3MBTL1 (0.57) | SCD5KDM4EALDH1A1HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349552-A1 | PYRAZOLO 3,4-D]PYRIMIDINE DERIVATIVES AND THEIR USE AS PURINERGIC RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002055082-A1 | PYRAZOLO[3,4-D]PYRIMIDINE DERIVATIVES AND THEIR USE AS PURINERGIC RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2002-07-18 | — | — | WO | disclosed |