Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 10/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7004006 | 0.83 | L3MBTL1 (0.64) | ADORA2AADORA1L3MBTL1SCDSCD5 | |
| SCHEMBL7092817 | 0.77 | SCD5 (0.45) | ADORA2AADORA1ADORA2BADORA3L3MBTL1 | |
| SCHEMBL7092854 | 0.74 | HDAC3 (0.49) | ADORA2AADORA1ADORA2BADORA3SIRT1 | |
| SCHEMBL7098488 | 0.73 | L3MBTL1 (0.57) | ADORA2AADORA1ADORA2BADORA3L3MBTL1 | |
| SCHEMBL7097845 | 0.73 | ADORA2A (0.43) | ADORA2AADORA1ADORA2BADORA3L3MBTL1 | |
| SCHEMBL6528550 | 0.72 | SIGMAR1 (0.44) | ADORA2AADORA1ADORA2BL3MBTL1 | |
| SCHEMBL31224806 | 0.72 | MAOB (0.47) | ADORA2AADORA1ADORA2BL3MBTL1 | |
| SCHEMBL7096885 | 0.71 | ADORA2A (0.52) | ADORA2AADORA1ADORA2BADORA3L3MBTL1 | |
| SCHEMBL6690784 | 0.71 | ADORA2A (0.50) | ADORA2AADORA1ADORA2BADORA3L3MBTL1 | |
| SCHEMBL15014142 | 0.71 | ADORA2A (0.46) | ADORA2AADORA1ADORA2BL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349552-A1 | PYRAZOLO 3,4-D]PYRIMIDINE DERIVATIVES AND THEIR USE AS PURINERGIC RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002055082-A1 | PYRAZOLO[3,4-D]PYRIMIDINE DERIVATIVES AND THEIR USE AS PURINERGIC RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2002-07-18 | — | — | WO | disclosed |