Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5212964 | 0.86 | ALDH1A1 (0.65) | ALDH1A1TSHRNPSR1MAPTHPGD | |
| SCHEMBL6258412 | 0.79 | ROCK2 (0.55) | MAPTHPGDGAAROCK2TP53 | |
| SCHEMBL6255361 | 0.76 | WDR5 (0.48) | MAPTROCK2TP53LMNANAMPT | |
| SCHEMBL7142998 | 0.75 | MEN1 (0.43) | MAOBPPARG | |
| SCHEMBL22774462 | 0.75 | POLB (0.62) | ALDH1A1MAPTHPGDGAAROCK2 | |
| SCHEMBL29453012 | 0.75 | POLB (0.62) | ALDH1A1MAPTHPGDGAAROCK2 | |
| SCHEMBL6258517 | 0.74 | ROS1 (0.48) | ALDH1A1MAPTLMNANAMPT | |
| SCHEMBL5329065 | 0.74 | LMNA (0.60) | ALDH1A1TSHRNPSR1MAPTHPGD | |
| SCHEMBL23985268 | 0.74 | ALDH1A1 (0.64) | ALDH1A1TSHRNPSR1MAPTHPGD | |
| SCHEMBL30305464 | 0.74 | ALDH1A1 (0.64) | ALDH1A1TSHRNPSR1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362033-A1 | PYRIDINE MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-11-19 | — | — | EP | claimed |
| WO-2002064568-A1 | PYRIDINE MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | claimed |