Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 7/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.50 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.50 |
| ▸ | CHRNG | P07510 | 2/20 | 0.50 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.50 |
| ▸ | CHRND | Q07001 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5954545 | 0.85 | SLC6A3 (0.66) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL4869220 | 0.84 | OPRD1 (0.53) | OPRD1OPRM1CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL5953978 | 0.84 | SLC6A2 (0.68) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| Hydrochloric Acid SCHEMBL27492948 | 0.83 | OPRD1 (0.52) | OPRD1OPRM1CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL5954170 | 0.83 | MC4R (0.57) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3800395 | 0.81 | ADRB2 (0.42) | OPRD1CHRNB2SLC6A2CHRNB4CHRNA3 | |
| SCHEMBL5954184 | 0.81 | PHGDH (0.55) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL9386877 | 0.78 | OPRD1 (0.49) | OPRD1OPRM1CYP2D6CYP19A1ALDH1A1 | |
| SCHEMBL29171164 | 0.77 | OPRD1 (0.45) | OPRD1OPRM1CYP2D6CYP19A1ALDH1A1 | |
| SCHEMBL10897567 | 0.76 | OPRD1 (0.57) | OPRD1OPRM1CYP2D6CYP19A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901469-B1 | ARYLALKYLPIPERAZINE COMPOUNDS AS ANTIOXIDANTS | UNIV MONASH (AU) | 2003-08-27 | — | — | EP | disclosed |
| US-6232314-B1 | SUCH AS 1-(2-(4-CHLOROPHENYL)-2-HYDROXY)ETHYL-4-(3,5-BIS(1,1-DIMETHYLETHYL)-4 -HYDROXYPHENYL)METHYLPIPERAZINE; USED TO TREAT STROKE, CARDIAC ARREST, ISCHAEMIA, HYPOXIA, HYPOGLYCAEMIA, EPILEPSY, AND AMYOTROPHIC LATERAL SCLEROSIS | MONASH UNIVERSITY (AU) | 2001-05-15 | — | — | US | disclosed |
| EP-0901469-A4 | ARYLALKYLPIPERAZINE COMPOUNDS AS ANTIOXIDANTS | UNIV MONASH (AU) | 2000-11-15 | — | — | EP | disclosed |
| EP-0901469-A1 | ARYLALKYLPIPERAZINE COMPOUNDS AS ANTIOXIDANTS | MONASH UNIVERSITY (AU) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997043259-A1 | ARYLALKYLPIPERAZINE COMPOUNDS AS ANTIOXIDANTS | MONASH UNIVERSITY (AU) | 1997-11-20 | — | — | WO | disclosed |