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SCHEMBL7094549

SCHEMBL7094549

CS(=O)(=O)Nc1cccc(N(c2ccccc2)C(C(N)=O)c2ccccc2)c1

nearest known ligand 0.52

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 P04150 1/20 0.52
▸ NR3C2 P08235 3/20 0.47
▸ ALDH1A1 P00352 2/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.46
▸ KEAP1 Q14145 1/20 0.45
▸ IKBKB O14920 1/20 0.45
▸ CHUK O15111 1/20 0.45
▸ POLB P06746 1/20 0.44
▸ HTR7 P34969 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7093211 0.96 NR3C1 (0.50) NR3C1NR3C2ALDH1A1SMN1; SMN2KEAP1
SCHEMBL7094981 0.90 NR3C2 (0.56) NR3C2ALDH1A1SMN1; SMN2KEAP1IKBKB
SCHEMBL7093909 0.78 TRPM8 (0.51) SMN1; SMN2
SCHEMBL7094551 0.78 NR3C1 (0.56) NR3C1NR3C2ALDH1A1SMN1; SMN2KEAP1
SCHEMBL7094118 0.76 TRPM8 (0.43) —
SCHEMBL7093212 0.76 NR3C1 (0.54) NR3C1NR3C2ALDH1A1SMN1; SMN2KEAP1
SCHEMBL7092758 0.75 TRPM8 (0.41) ALDH1A1SMN1; SMN2
SCHEMBL8867745 0.74 ALDH1A1 (0.54) NR3C1ALDH1A1SMN1; SMN2KEAP1IKBKB
SCHEMBL11466281 0.74 ALDH1A1 (0.54) NR3C1ALDH1A1SMN1; SMN2KEAP1IKBKB
SCHEMBL8867750 0.74 ALDH1A1 (0.54) NR3C1ALDH1A1SMN1; SMN2KEAP1IKBKB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003082777-A2 NOVEL GLUCOCORTICOID RECEPTOR LIGANDS KARO BIO AB (SE) 2003-10-09 — — WO claimed
WO-2003082777-A2 NOVEL GLUCOCORTICOID RECEPTOR LIGANDS KARO BIO AB (SE) 2003-10-09 — — WO disclosed