Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | RGS12 | O14924 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11804600 | 0.74 | CHRM2 (0.49) | — | |
| SCHEMBL19659716 | 0.74 | RIPK1 (0.36) | LMNACYP1A2CYP2D6 | |
| SCHEMBL11751501 | 0.71 | MGLL (0.45) | SLC6A2SLC6A4SLC6A3CYP2D6ADRA1A | |
| SCHEMBL11434562 | 0.71 | SLC6A2 (0.52) | EEF2KSLC6A2SLC6A4SLC6A3LMNA | |
| SCHEMBL4347105 | 0.70 | EEF2K (0.43) | EEF2K | |
| SCHEMBL8459602 | 0.70 | HRH3 (0.36) | SLC6A2SLC6A4SLC6A3ADRA1AOPRM1 | |
| SCHEMBL11602931 | 0.70 | DRD1 (0.39) | SLC6A2SLC6A4SLC6A3HTR2A | |
| Hydrochloric Acid SCHEMBL11600984 | 0.69 | DRD1 (0.40) | SLC6A2SLC6A4SLC6A3HTR2A | |
| SCHEMBL7834022 | 0.67 | TSHR (0.49) | EEF2KSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13068262 | 0.66 | NOTUM (0.53) | SLC6A2SLC6A4SLC6A3RGS12LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124621-B2 | Substituted 1-amino-4-phenyl-dihydroisoquinolines, methods for the production thereof, use thereof as a medicament, and medicaments containing them | SANOFI-AVENTIS (FR) | 2012-02-28 | — | — | US | disclosed |
| US-20090118327-A1 | SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHODS FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM | SANOFI-AVENTIS (FR) | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118327-A1 | SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHODS FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM | NDUFAB1, ABCB11, SLC10A1 | EEF2K 2216/4885SLC6A2 169/4885SLC6A4 302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.