SCHEMBL7097939

SCHEMBL7097939

Nc1nc(S)nc(N)c1Cc1ccc(F)cc1.[KH]

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
CYP2D6 P10635 1/20 0.44
ATM Q13315 1/20 0.44
IDO1 P14902 2/20 0.42
DHFR P00374 1/20 0.38
LOXL2 Q9Y4K0 1/20 0.38
MPO P05164 1/20 0.37
CCR2 P41597 1/20 0.36
DPP4 P27487 1/20 0.36
TAAR1 Q96RJ0 1/20 0.35
HTR6 P50406 1/20 0.35
AGXT P21549 1/20 0.34
MEN1 O00255 1/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
KMT2A Q03164 1/20 0.34
MGMT P16455 1/20 0.34
MAP4K4 O95819 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7093887 0.82 HSP90AB1 (0.45) ALDH1A1CYP2D6ATMIDO1DHFR
SCHEMBL7092922 0.78 ALDH1A1 (0.50) ALDH1A1CYP2D6ATMNPC1RAB9A
SCHEMBL7097439 0.78 ALDH1A1 (0.73) ALDH1A1CYP2D6ATMIDO1DHFR
SCHEMBL7093994 0.76 ALDH1A1 (0.45) ALDH1A1CYP2D6ATMIDO1DHFR
SCHEMBL1442589 0.70 L3MBTL1 (0.67) ALDH1A1ATMDPP4NPC1RAB9A
SCHEMBL12496103 0.69 SMN1; SMN2 (0.59) ALDH1A1CYP2D6ATMDHFRLOXL2
SCHEMBL9287333 0.69 NPSR1 (0.53) ALDH1A1CYP2D6ATMHTR6
SCHEMBL10776095 0.69 ALDH1A1 (0.40) ALDH1A1CYP2D6DHFRMEN1KMT2A
SCHEMBL3706897 0.68 MAPT (0.46) ALDH1A1IDO1LOXL2MPOCCR2
Sampirtine SCHEMBL29973209 0.67 MPO (0.49) IDO1LOXL2MPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1194415-B1 NOVEL PIPERAZINYLALKYLTHIOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND A PROCESS FOR THEIR PREPARATION EGYT GYOGYSZERVEGYESZETI GYAR (HU) 2003-08-20 EP disclosed
US-6469168-B1 FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, ESPECIALLY ANXIETY EGIS Gyógyszergyár Rt. (HU) 2002-10-22 US disclosed
EP-1194415-A2 NOVEL PIPERAZINYLALKYLTHIOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND A PROCESS FOR THEIR PREPARATION Egis Gyogyszergyar Rt. (HU) 2002-04-10 EP disclosed
WO-2001000617-A2 NOVEL PIPERAZINYLALKYLTHIOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND A PROCESS FOR THE PREPARATION OF THE SAME EGIS Gyógyszergyár Rt. (HU) 2001-01-04 WO disclosed