Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7100584 | 0.97 | CA2 (0.46) | CA2RECQLCA1TP53ALDH1A1 | |
| Potassium Ion SCHEMBL7100337 | 0.91 | CYP3A4 (0.31) | TSHRCYP3A4NFKB1NPSR1 | |
| SCHEMBL7102067 | 0.88 | CYP3A4 (0.33) | CA2CA1TSHRCYP3A4NFKB1 | |
| SCHEMBL9838460 | 0.86 | CA2 (0.41) | CA2RECQLCA1TP53TSHR | |
| Potassium Ion SCHEMBL7095225 | 0.85 | CA1 (0.45) | CA2CA1TP53TSHRCYP3A4 | |
| SCHEMBL7102088 | 0.82 | CA1 (0.47) | CA2CA1TP53TSHRCYP3A4 | |
| Ammonia Solution, Strong SCHEMBL7099683 | 0.81 | RECQL (0.39) | CA2RECQLTP53ALDH1A1TSHR | |
| Potassium Ion SCHEMBL11581377 | 0.80 | CYP3A4 (0.31) | TSHRCYP3A4NFKB1NPSR1 | |
| Potassium Ion SCHEMBL817853 | 0.77 | CA2 (0.43) | CA2RECQLCA1ALDH1A1TSHR | |
| Monoethanolamine SCHEMBL7095004 | 0.76 | RECQL (0.35) | CA2RECQLTP53ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0964036-B1 | Water-based ball-point pen ink composition | PILOT INK CO LTD (JP) | 2003-08-27 | — | — | EP | disclosed |
| US-6261352-B1 | BETAINE, SULFO ESTER | THE PILOT INK CO., LTD. (JP) | 2001-07-17 | — | — | US | disclosed |
| EP-0964036-A2 | Water-based ball-point pen ink composition | THE PILOT INK CO., LTD. (JP) | 1999-12-15 | — | — | EP | disclosed |