Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 11/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 5/20 | 1.00 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GLI1 | P08151 | 1/20 | 0.43 |
| ▸ | GLI2 | P10070 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7101712 | 0.93 | OPRK1 (1.00) | OPRK1OPRD1MMP8POLBCYP2C9 | |
| SCHEMBL7102313 | 0.88 | OPRK1 (1.00) | OPRK1OPRD1MMP1MMP2MMP9 | |
| SCHEMBL7105487 | 0.79 | OPRK1 (0.64) | OPRK1OPRD1 | |
| SCHEMBL7101012 | 0.79 | OPRK1 (1.00) | OPRK1OPRD1POLBRAB9ALMNA | |
| SCHEMBL7106995 | 0.78 | OPRK1 (0.89) | OPRK1OPRD1MMP1MMP2MMP9 | |
| SCHEMBL7106593 | 0.78 | OPRK1 (0.75) | OPRK1OPRD1MMP1MMP2MMP9 | |
| SCHEMBL7106526 | 0.76 | OPRK1 (1.00) | OPRK1OPRD1MAPTLMNA | |
| SCHEMBL7108645 | 0.76 | OPRK1 (1.00) | OPRK1OPRD1MMP1MMP2MMP9 | |
| SCHEMBL7108642 | 0.76 | OPRK1 (1.00) | OPRK1OPRD1NPC1 | |
| SCHEMBL13774782 | 0.74 | OPRK1 (0.68) | OPRK1OPRD1MMP8POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1055665-B1 | 3-(3-Hydroxyphenyl)-3-amino-propionamide derivatives | PFIZER PROD INC (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-1055665-A1 | 3-(3-Hydroxyphenyl)-3-amino-propionamide derivatives | Pfizer Products Inc. (US) | 2000-11-29 | — | — | EP | disclosed |