Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 2/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.50 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4A | O75164 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7868722 | 0.91 | LMNA (0.49) | LMNAHSD17B10ALDH1A1POLBCRHBP | |
| SCHEMBL4935067 | 0.85 | LMNA (0.61) | LMNAHSD17B10ALDH1A1POLBCRHBP | |
| SCHEMBL9872058 | 0.84 | ALDH1A1 (0.53) | LMNAHSD17B10ALDH1A1POLBCRHBP | |
| SCHEMBL15828137 | 0.84 | LMNA (0.53) | LMNAHSD17B10ALDH1A1POLBCRHBP | |
| SCHEMBL9240062 | 0.84 | CYP2C19 (0.48) | LMNAHSD17B10ALDH1A1POLBCRHBP | |
| SCHEMBL8079874 | 0.84 | CYP2C19 (0.48) | LMNAHSD17B10ALDH1A1POLBCRHBP | |
| SCHEMBL3516105 | 0.83 | LMNA (0.56) | LMNAHSD17B10ALDH1A1POLBCRHBP | |
| SCHEMBL1715 | 0.83 | LMNA (0.59) | LMNAHSD17B10ALDH1A1POLBCRHBP | |
| SCHEMBL20769804 | 0.83 | LMNA (0.59) | LMNAHSD17B10ALDH1A1POLBCRHBP | |
| SCHEMBL65737 | 0.83 | LMNA (0.59) | LMNAHSD17B10ALDH1A1POLBCRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0926127-B1 | Process for the preparation of acyclic alpha,beta-dicarbonyl compounds | CLARIANT FRANCE SA (FR) | 2001-10-04 | — | — | EP | claimed |
| EP-0273202-B1 | Use of hydroxycarboxylic acids to enhance therapeutic effects of topical compositions for fungal infections and pigmented spots. | SCOTT EUGENE J VAN (US) | 1995-06-21 | — | — | EP | claimed |
| EP-1727516-B1 | COMPOSITION COMPRISING AN HDAC INHIBITOR IN COMBINATION WITH A RETINOID | DSM IP ASSETS BV (NL) | 2014-05-14 | — | — | EP | disclosed |
| CN-101914023-B | Preparation method of optically pure 4-aryl-2-hydroxy-butyric ester | UNIV SHANGHAI JIAOTONG | 2013-05-22 | — | — | CN | disclosed |
| US-8124802-B2 | e.g. N-methyl-N-propargyl-4-hydroxybenzyl amine; monoamine oxidase inhibitors; are mediated via a peripheral (i.e., non-CNS) mechanism; antidiabetic agent, metabolic disordes, obesity, insulin resistance | JENRIN DISCOVERY, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| WO-2011009849-A2 | METHOD FOR PREPARING OPTICALLY ACTIVE HYDROXY ACID ESTERS | BASF SE (DE) | 2011-01-27 | — | — | WO | disclosed |
| EP-1437401-B1 | Oxidoreductase | IEP GMBH (DE) | 2010-12-15 | — | — | EP | disclosed |
| CN-101914023-A | Preparation method of optically pure 4-aryl-2-hydroxy-butyric ester | UNIV SHANGHAI JIAOTONG | 2010-12-15 | — | — | CN | disclosed |
| US-20100286278-A1 | Composition comprising an HDAC inhibitor in combination with a retinoid | DSM IP ASSETS B.V. (NL) | 2010-11-11 | — | — | US | disclosed |
| EP-1602354-B1 | Use of polyglutamic acid or its salts | MEIJI SEIKA KAISHA (JP) | 2008-11-05 | — | — | EP | disclosed |
| US-20080227868-A1 | Composition Comprising an Hdac Inhibitor in Combination with a Retinoid | DSM IP ASSETS B.V. (NL) | 2008-09-18 | — | — | US | disclosed |
| US-20060165636-A1 | Hair treatment composition and hair cosmetic for damaged hair | MEIJI SEIKA KAISHA, LTD. (JP) | 2006-07-27 | — | — | US | disclosed |
| EP-1602354-A1 | HAIR TREATMENT COMPOSITION AND HAIR COSMETIC FOR DAMAGED HAIR | Meiji Seika Kaisha, Ltd. (JP) | 2005-12-07 | — | — | EP | disclosed |
| WO-2005092283-A1 | COMPOSITION COMPRISING AN HDAC INHIBITOR IN COMBINATION WITH A RETINOID | DSM IP ASSETS B.V. (NL) | 2005-10-06 | — | — | WO | disclosed |
| US-20050191735-A1 | Oxidoreductase | IEP GMBH (DE) | 2005-09-01 | — | — | US | disclosed |
| EP-1437401-A1 | Oxidoreductase | Juelich Enzyme Products GmbH (DE) | 2004-07-14 | — | — | EP | disclosed |
| EP-0407588-B1 | PROCESS FOR PRODUCING 2-OXO-3-AROMATIC CARBOXYLIC ACID DERIVATIVES | SAGAMI CHEM RES (JP) | 1993-12-08 | — | — | EP | disclosed |
| US-5028738-A | Process for producing 2-oxo-3-aromatic carboxylic acid derivatives | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1991-07-02 | — | — | US | disclosed |
| EP-0407588-A1 | PROCESS FOR PRODUCING 2-OXO-3-AROMATIC CARBOXYLIC ACID DERIVATIVES | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1991-01-16 | — | — | EP | disclosed |
| EP-0386243-A1 | PLATINUM (II) COMPLEXES | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1990-09-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286278-A1 | Composition comprising an HDAC inhibitor in combination with a retinoid | HDAC7, HDAC5, HDAC1 | LMNA 284/4885HSD17B10 192/4885ALDH1A1 259/4885 |
| US-20080227868-A1 | Composition Comprising an Hdac Inhibitor in Combination with a Retinoid | HDAC7, HDAC5, HDAC1 | LMNA 284/4885HSD17B10 192/4885ALDH1A1 259/4885 |
| US-20060165636-A1 | Hair treatment composition and hair cosmetic for damaged hair | CUTA, COL14A1, PRKDC | LMNA 2112/4885HSD17B10 888/4885ALDH1A1 2963/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.