Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9597294 | 0.84 | TRPM8 (0.47) | TRPM8ALDH1A1SMN1; SMN2MMP1MMP2 | |
| SCHEMBL7109134 | 0.84 | KDM4E (0.44) | TRPM8NPC1ALDH1A1RAB9A | |
| SCHEMBL11552690 | 0.81 | NPC1 (0.50) | TRPM8NPC1ALDH1A1GLAHTT | |
| SCHEMBL8068374 | 0.77 | CHRM2 (0.41) | TRPM8NPC1ALDH1A1GLAHTT | |
| SCHEMBL8068379 | 0.77 | PDK1 (0.46) | TRPM8NPC1ALDH1A1GLAHTT | |
| SCHEMBL1925076 | 0.76 | ALDH1A1 (0.59) | TRPM8NPC1ALDH1A1GLAHTT | |
| SCHEMBL9595675 | 0.75 | MMP1 (0.55) | NPC1ALDH1A1RAB9ASMN1; SMN2MMP1 | |
| SCHEMBL9595673 | 0.75 | MMP1 (0.55) | NPC1ALDH1A1RAB9ASMN1; SMN2MMP1 | |
| SCHEMBL8721921 | 0.75 | TRPM8 (1.00) | TRPM8NPC1ALDH1A1GLAHTT | |
| SCHEMBL8721927 | 0.75 | TRPM8 (1.00) | TRPM8NPC1ALDH1A1GLAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1013639-B1 | Aryl carboxylic acid and tetrazole derivatives comprising a carbamoyloxy unit | HOFFMANN LA ROCHE (CH) | 2003-10-01 | — | — | EP | disclosed |
| US-6335459-B1 | PROSTAGLANDIN I2 RECEPTOR MODULATORS; TREATING TISSUE NECROSIS, PREMATURE UTERINE CONTRACTION, GASTRIC ULCERATION, SEXUAL DYSFUNCTION, MENSTRUAL PAIN AND IMPROPER WOUND HEALING, IMMUNOREGULATION, PLATELET AGGREGATION OR NEUTROPHIL FUNCTION | SYNTEX (U.S.A.) LLC | 2002-01-01 | — | — | US | disclosed |