SCHEMBL7107798

SCHEMBL7107798

Clc1ccc(C2N(Cc3ccccc3)CCN2Cc2ccccc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.58
MDM2 Q00987 1/20 0.58
SIGMAR1 Q99720 2/20 0.55
RORC P51449 1/20 0.55
MEN1 O00255 2/20 0.49
KMT2A Q03164 2/20 0.49
POLB P06746 1/20 0.48
LMNA P02545 1/20 0.48
HTT P42858 1/20 0.48
ALDH1A1 P00352 1/20 0.47
DRD4 P21917 2/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
BCHE P06276 1/20 0.44
ACHE P22303 1/20 0.44
BACE1 P56817 1/20 0.44
CCR3 P51677 1/20 0.43
KDM1A O60341 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL819498 0.89 TP53 (0.70) TP53MDM2SIGMAR1RORCPOLB
SCHEMBL14371819 0.83 MAPT (0.50) RORCLMNADRD4CYP1A2CYP2D6
SCHEMBL2936024 0.81 TP53 (0.61) TP53MDM2SIGMAR1
SCHEMBL14124508 0.81 TP53 (0.60) TP53MDM2SIGMAR1RORCPOLB
SCHEMBL14373042 0.80 TP53 (0.52) TP53MDM2POLBLMNAHTT
SCHEMBL14373274 0.80 RORC (0.58) TP53MDM2SIGMAR1RORCPOLB
SCHEMBL18719826 0.80 SIGMAR1 (0.59) TP53MDM2SIGMAR1RORCMEN1
SCHEMBL7150920 0.80 TP53 (0.56) TP53MDM2SIGMAR1RORCPOLB
SCHEMBL28824752 0.79 SIGMAR1 (0.50) SIGMAR1RORCMEN1KMT2AALDH1A1
SCHEMBL23064641 0.77 DRD2 (0.54) SIGMAR1RORCMEN1KMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1042332-B1 PRODUCTION OF ORGANOMAGNESIUM COMPOUNDS USING CATALYSTS STUDIENGESELLSCHAFT KOHLE MBH (DE) 2003-09-24 EP disclosed
US-6221285-B1 SALT FORMATION WITH ORGANIC HALIDES REACTED WITH MAGNESIUM STUDIENGESELLSCHAFT KOHLE MBH (DE) 2001-04-24 US disclosed
EP-1042332-A1 PRODUCTION OF ORGANOMAGNESIUM COMPOUNDS USING CATALYSTS Studiengesellschaft Kohle mbH (DE) 2000-10-11 EP disclosed
US-6117372-A REACTING AN ORGANIC HALIDE WITH MAGNESIUM METAL IN AN ETHER SOLVENT IN THE PRESENCE OF AN INORGANIC GRIGNARD REAGENT CATALYST, A TRANSITION METAL-MAGNSIUM CHLORIDE COMPLEX PREPARED BY REACTING A TRANSITION METAL HALIDE WITH MAGNESIUM STUDIENGESELLSCHAFT KOHLE MBH (DE) 2000-09-12 US disclosed
WO-1999033844-A1 PRODUCTION OF ORGANOMAGNESIUM COMPOUNDS USING CATALYSTS STUDIENGESELLSCHAFT KOHLE MBH (DE) 1999-07-08 WO disclosed