Tmpyp4

SCHEMBL7112191

C[n+]1ccc(-c2c3nc(c(-c4cc[n+](C)cc4)c4ccc([nH]4)c(-c4cc[n+](C)cc4)c4nc(c(-c5cc[n+](C)cc5)c5ccc2[nH]5)C=C4)C=C3)cc1.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccc(S(=O)(=O)O)cc1.Cc1ccc(S(=O)(=O)O)cc1

nearest known ligand 0.80

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1 BMX BRAF BTK CHRNA4 CHRNB2 CSNK1E EGFR ERBB2 F10 FLT1 FLT3 FLT4 IGF1R INSR ITK JAK3 KDR KIT OPRM1 PARP1 PARP2 PDGFRB PIK3CD RAF1 RET SLC18A2 TEC TXK dacA dacB dacC ftsI mrcA mrcB mrdA rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Tmpyp4. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	TERT	O14746	6/20	0.80

▸	ENPP2	Q13822	1/20	0.68

▸	TOP1	P11387	4/20	0.44

▸	CYCS	P99999	3/20	0.43

▸	ABCG2	Q9UNQ0	1/20	0.43

▸	KDM4E	B2RXH2	1/20	0.40

▸	ALDH1A1	P00352	1/20	0.40

▸	LMNA	P02545	1/20	0.40

▸	MAPT	P10636	1/20	0.40

▸	HTT	P42858	1/20	0.40

▸	SMN1; SMN2	Q16637	1/20	0.40

▸	TDP1	Q9NUW8	1/20	0.40

▸	L3MBTL1	Q9Y468	1/20	0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Tmpyp4 SCHEMBL3792658	1.00	TERT (0.80)	TERTENPP2TOP1CYCSABCG2
SCHEMBL2737183	0.90	ENPP2 (0.84)	TERTENPP2TOP1CYCSABCG2
Tmpyp4 SCHEMBL8153900	0.89	TERT (1.00)	TERTENPP2TOP1CYCSABCG2
Tmpyp4 SCHEMBL30632001	0.89	TERT (1.00)	TERTENPP2TOP1CYCSABCG2
Tmpyp4 SCHEMBL6045450	0.88	TERT (0.98)	TERTENPP2TOP1CYCSABCG2
SCHEMBL18016429	0.86	TERT (0.82)	TERTENPP2TOP1CYCSABCG2
SCHEMBL15943766	0.85	ENPP2 (0.76)	TERTENPP2TOP1CYCSABCG2
Hydrochloric Acid SCHEMBL29881399	0.83	ENPP2 (0.91)	TERTENPP2TOP1CYCSABCG2
SCHEMBL29368142	0.83	ENPP2 (0.97)	TERTENPP2TOP1CYCSABCG2
SCHEMBL218702	0.83	ENPP2 (0.97)	TERTENPP2TOP1CYCSABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-6677043-B2	HAS THE SURFACE COVERED WITH AN ULTRATHIN FILM CONTAINING OXYGEN-METAL BOND; IMPROVED PROPERTIES SUCH ASSOLUBILITY, MISCIBILITY, STIFFNESS, ADSORPTION PROPERTY, VISCOELASTICIT PROPERTY, ELECTRON MOBILITY, FLUORESCENCE, REACTIVITY, ETC.	RIKEN (JP)	2004-01-13	—	—	US	disclosed