SCHEMBL7112522

SCHEMBL7112522

O=C1CCc2c[c]ccc2C2=C1CCC2

nearest known ligand 0.35

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.35
MAOB P27338 2/20 0.35
CYP2A6 P11509 1/20 0.35
CASP1 P29466 1/20 0.33
CASP7 P55210 1/20 0.33
HSD17B10 Q99714 1/20 0.33
PRKCI P41743 1/20 0.32
HSD17B1 P14061 1/20 0.30
PBRM1 Q86U86 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1380751 0.85 CASP1 (0.44) MAOAMAOBCYP2A6CASP1CASP7
SCHEMBL1891844 0.82 MAOA (0.53) MAOAMAOBCYP2A6PRKCIHSD17B1
SCHEMBL22367713 0.75
SCHEMBL134194 0.74
SCHEMBL1451149 0.70 PBRM1 (0.44) MAOAMAOBCYP2A6CASP1CASP7
SCHEMBL11849586 0.69 MAOB (0.68) MAOAMAOBCYP2A6PRKCI
SCHEMBL5203864 0.69 MAOB (0.69) MAOAMAOBCASP1CASP7HSD17B10
SCHEMBL7974509 0.69 CASP1 (0.44) MAOAMAOBCYP2A6CASP1CASP7
SCHEMBL23277084 0.69 PBRM1 (0.33) MAOAMAOBCYP2A6CASP1CASP7
SCHEMBL8162675 0.68 CES1 (0.61) MAOAMAOBCYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1017681-B1 HYDRAZONO-BENZAZULENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND INTERMEDIATES AVENTIS PHARMA SA (FR) 2003-04-09 EP disclosed
EP-0888292-A1 TRICYCLIC COMPOUNDS HAVING ACTIVITY SPECIFIC FOR INTEGRINS, PARTICULARLY $g(a)v$g(b)3 INTEGRINS, METHOD FOR PREPARING SAME, INTERMEDIATES THEREFOR, USE OF SAID COMPOUNDS AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME HOECHST MARION ROUSSEL (FR) 1999-01-07 EP disclosed
WO-1997034865-A1 TRICYCLIC COMPOUNDS HAVING ACTIVITY SPECIFIC FOR INTEGRINS, PARTICULARLY αvβ3 INTEGRINS, METHOD FOR PREPARING SAME, INTERMEDIATES THEREFOR, USE OF SAID COMPOUNDS AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME HOECHST MARION ROUSSEL (FR) 1997-09-25 WO disclosed