Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31287752 | 0.73 | CA2 (0.51) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2703947 | 0.73 | CYP2A6 (0.47) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1034849 | 0.73 | CA2 (0.51) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6572028 | 0.73 | SLC1A3 (0.57) | CA1CA2ALDH1A1HTTSLC1A3 | |
| SCHEMBL28046230 | 0.72 | TTR (0.45) | HDAC3HSD17B10SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL6766434 | 0.72 | CYP2A6 (0.46) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6617627 | 0.72 | CYP2A6 (0.46) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Hydrochloric Acid SCHEMBL27734063 | 0.72 | CYP2A6 (0.46) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4251872 | 0.71 | ALOX5 (0.54) | ALOX5HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL14089195 | 0.70 | CYP2A6 (0.46) | ALOX5HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6800623-B2 | A 1,3-DITHIA-4-AZA-ACENAPHTHYLENE 3,3-DIOXIDE COMPOUNDS; TREATING PSYCHOLOGICAL DISORDERS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2004-10-05 | — | — | US | disclosed |
| US-20030158183-A1 | Method of treating schizophrenia | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-08-21 | — | — | US | disclosed |
| US-20030158181-A1 | Method for treating cerebral ishaemia | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-08-21 | — | — | US | disclosed |
| US-6525045-B2 | 4,5-dihydro-1,3-dithia-4-aza-acenaphthylene-3,3-dioxide compounds for example; treating ischemia, Alzheimer's disease, schizophrenia; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-02-25 | — | — | US | disclosed |
| US-20020013313-A1 | 4,5-dihydro-1,3-dithia-4-aza-acenaphthylene-3,3-dioxide compounds for example; treating ischemia, Alzheimer's disease, schizophrenia; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2002-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030158183-A1 | Method of treating schizophrenia | GRIN2A, GRIN1, CHAT | ALOX5 2416/4885HDAC3 1382/4885HDAC4 1330/4885 |
| US-20020013313-A1 | 4,5-dihydro-1,3-dithia-4-aza-acenaphthylene-3,3-dioxide compounds for example; treating ischemia, Alzheimer's disease, schizophrenia; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) | GRIA4, GRIN1, GRIN3A | ALOX5 2073/4885HDAC3 1090/4885HDAC4 1052/4885 |
| US-20030158181-A1 | Method for treating cerebral ishaemia | PYGB, DCX, INA | ALOX5 4250/4885HDAC3 1124/4885HDAC4 1569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.