SCHEMBL7117206

SCHEMBL7117206

CC(C)Nc1nc2ccc([N+](=O)[O-])cc2n1[C@@H]1O[C@H](C)[C@@H](O)[C@H]1O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 1/20 0.48
SLC29A1 Q99808 1/20 0.39
IRAK4 Q9NWZ3 1/20 0.38
TRPV4 Q9HBA0 1/20 0.37
MAPT P10636 3/20 0.36
ALDH1A1 P00352 2/20 0.36
NPC1 O15118 1/20 0.36
NPBWR1 P48145 1/20 0.36
RAB9A P51151 1/20 0.36
MCHR1 Q99705 1/20 0.36
ADK P55263 1/20 0.35
BRD4 O60885 1/20 0.35
IDH1 O75874 2/20 0.35
LMNA P02545 2/20 0.35
NPSR1 Q6W5P4 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
KCNH3 Q9ULD8 1/20 0.34
GUCY1B2 O75343 1/20 0.34
GUCY1A2 P33402 1/20 0.34
GUCY1A1 Q02108 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7118656 0.93 HDAC6 (0.48) HDAC6SLC29A1IRAK4TRPV4MAPT
SCHEMBL7742258 0.83 HDAC6 (0.57) HDAC6MAPTALDH1A1ADKNPSR1
SCHEMBL7733484 0.80 HDAC6 (0.49) HDAC6TRPV4ADKIDH1
SCHEMBL7114288 0.80 HDAC6 (0.49) HDAC6TRPV4MCHR1IDH1
SCHEMBL7738034 0.78 HDAC6 (0.56) HDAC6MAPTLMNASMN1; SMN2
SCHEMBL7215024 0.78 HDAC6 (0.74) HDAC6TRPV4ADK
SCHEMBL7215020 0.78 HDAC6 (0.74) HDAC6TRPV4ADK
SCHEMBL7734525 0.77 HDAC6 (0.57) HDAC6TRPV4MAPTADK
SCHEMBL7120051 0.76 TRPV4 (0.38) HDAC6IRAK4TRPV4MAPTALDH1A1
SCHEMBL7739904 0.75 HDAC6 (0.63) HDAC6TRPV4MAPTLMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0970100-B1 BENZIMIDAZOLE DERIVATIVES GLAXO GROUP LTD (GB) 2003-11-12 EP claimed
US-6413938-B1 HERPES VIRUS THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2002-07-02 US claimed
EP-0970100-B1 BENZIMIDAZOLE DERIVATIVES GLAXO GROUP LTD (GB) 2003-11-12 EP disclosed
US-6413938-B1 HERPES VIRUS THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2002-07-02 US disclosed
EP-0970100-A1 BENZIMIDAZOLE DERIVATIVES GLAXO GROUP LIMITED (GB) 2000-01-12 EP disclosed
WO-1998035977-A1 BENZIMIDAZOLE DERIVATIVES GLAXO GROUP LIMITED (GB) 1998-08-20 WO disclosed