Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 3/20 | 0.39 |
| ▸ | RARA | P10276 | 1/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12707707 | 0.87 | MPL (0.36) | RARBNPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL12707678 | 0.87 | NISCH (0.36) | RARBMCL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18779777 | 0.82 | CTSL (0.41) | RARBRARARARGMCL1NPC1 | |
| SCHEMBL16377223 | 0.82 | CTSL (0.41) | RARBRARARARGMCL1NPC1 | |
| SCHEMBL20012960 | 0.82 | RARB (0.41) | RARBRARARARGMCL1NPC1 | |
| SCHEMBL9926822 | 0.81 | PDE3B (0.39) | NPC1RAB9ASMN1; SMN2PDE3BPDE3A | |
| SCHEMBL16377234 | 0.81 | RARB (0.47) | RARBRARARARGMCL1NPC1 | |
| SCHEMBL16377221 | 0.81 | RARB (0.43) | RARBRARARARGMCL1NPC1 | |
| SCHEMBL712607 | 0.81 | RARB (0.40) | RARBRARARARGMCL1NPC1 | |
| SCHEMBL20013004 | 0.81 | MCL1 (0.50) | RARBRARARARGMCL1CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8350100-B2 | Process for the preparation of ring compounds | MERCK PATENT GMBH (DE) | 2013-01-08 | — | — | US | disclosed |
| US-20120149943-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | MERCK GMBH (DE) | 2012-06-14 | — | — | US | disclosed |
| US-8124817-B2 | Process for the preparation of ring compounds | MERCK PATENT GMBH (DE) | 2012-02-28 | — | — | US | disclosed |
| EP-2332944-A2 | Process for the preparation of ring compounds | Merck Patent GmbH (DE) | 2011-06-15 | — | — | EP | disclosed |
| US-20110034738-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | PAULUTH DETLEF | 2011-02-10 | — | — | US | disclosed |
| US-7786332-B2 | Process for the preparation of ring compounds | MERCK PATENT GMBH (DE) | 2010-08-31 | — | — | US | disclosed |
| US-20090318727-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | PAULUTH DETLEF | 2009-12-24 | — | — | US | disclosed |
| EP-2103589-A1 | Polypenylenes as liquid crystals | Merck Patent GmbH (DE) | 2009-09-23 | — | — | EP | disclosed |
| US-20080319235-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | PAULUTH DETLEF | 2008-12-25 | — | — | US | disclosed |
| US-7411100-B2 | Process for the preparation of ring compounds | MERCK GMBH (DE) | 2008-08-12 | — | — | US | disclosed |
| US-7183447-B2 | Process for the preparation of ring compounds | MERCK PATENT GMBH (DE) | 2007-02-27 | — | — | US | disclosed |
| US-20060216754-A1 | Process for the preparation of ring compounds | PAULUTH DETLEF | 2006-09-28 | — | — | US | disclosed |
| US-20040006235-A1 | Process for the preparation of ring compounds | MERCK PATENT GMBH (DE) | 2004-01-08 | — | — | US | disclosed |
| EP-1346995-A1 | Process for the preparation of ring compounds | MERCK PATENT GmbH (DE) | 2003-09-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006235-A1 | Process for the preparation of ring compounds | NBAS, HDHD5, DBF4 | RARB 58/4885RARA 107/4885RARG 165/4885 |
| US-20120149943-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | NBAS, HDHD5, DBF4 | RARB 54/4885RARA 99/4885RARG 151/4885 |
| US-20080319235-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | NBAS, HDHD5, DBF4 | RARB 58/4885RARA 107/4885RARG 165/4885 |
| US-20110034738-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | NBAS, HDHD5, DBF4 | RARB 58/4885RARA 107/4885RARG 165/4885 |
| US-20090318727-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | NBAS, HDHD5, DBF4 | RARB 58/4885RARA 107/4885RARG 165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.