Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL711925 | 0.81 | RARB (0.39) | PDE3BPDE3ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12315382 | 0.81 | PTGS2 (0.44) | PDE3BPDE3ARPS6KA3DHODHCYP11B1 | |
| SCHEMBL13156763 | 0.80 | PDE3B (0.37) | PDE3BPDE3ARPS6KA3DHODHCYP11B1 | |
| SCHEMBL9926823 | 0.78 | PDE3B (0.35) | PDE3BPDE3AMEN1NPC1NFKB1 | |
| SCHEMBL19935706 | 0.78 | DHODH (0.44) | PDE3BPDE3AMEN1NPC1RAB9A | |
| SCHEMBL12092807 | 0.77 | PTGS2 (0.42) | PDE3BPDE3ARPS6KA3DHODHPTGS2 | |
| SCHEMBL20312883 | 0.77 | PTGS2 (0.40) | PDE3BPDE3ARPS6KA3DHODHPTGS2 | |
| SCHEMBL712453 | 0.76 | ALOX5AP (0.36) | PDE3BPDE3ANPC1 | |
| SCHEMBL14074141 | 0.76 | PDE3B (0.42) | PDE3BPDE3ASMN1; SMN2RPS6KA3CYP11B1 | |
| SCHEMBL21771748 | 0.76 | AKR1C3 (0.39) | PDE3BPDE3ARPS6KA3PTGS2PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8350100-B2 | Process for the preparation of ring compounds | MERCK PATENT GMBH (DE) | 2013-01-08 | — | — | US | disclosed |
| US-20120149943-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | MERCK GMBH (DE) | 2012-06-14 | — | — | US | disclosed |
| US-8124817-B2 | Process for the preparation of ring compounds | MERCK PATENT GMBH (DE) | 2012-02-28 | — | — | US | disclosed |
| US-20110034738-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | PAULUTH DETLEF | 2011-02-10 | — | — | US | disclosed |
| US-7842845-B2 | Process for the preparation of ring compounds | MERCK GMBH (DE) | 2010-11-30 | — | — | US | disclosed |
| US-7786332-B2 | Process for the preparation of ring compounds | MERCK PATENT GMBH (DE) | 2010-08-31 | — | — | US | disclosed |
| US-20090318727-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | PAULUTH DETLEF | 2009-12-24 | — | — | US | disclosed |
| US-20080319235-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | PAULUTH DETLEF | 2008-12-25 | — | — | US | disclosed |
| US-7411100-B2 | Process for the preparation of ring compounds | MERCK GMBH (DE) | 2008-08-12 | — | — | US | disclosed |
| US-7183447-B2 | Process for the preparation of ring compounds | MERCK PATENT GMBH (DE) | 2007-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149943-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | NBAS, HDHD5, DBF4 | PDE3B 3909/4885PDE3A 4006/4885MEN1 174/4885 |
| US-20080319235-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | NBAS, HDHD5, DBF4 | PDE3B 3888/4885PDE3A 3974/4885MEN1 160/4885 |
| US-20110034738-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | NBAS, HDHD5, DBF4 | PDE3B 3888/4885PDE3A 3974/4885MEN1 160/4885 |
| US-20090318727-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | NBAS, HDHD5, DBF4 | PDE3B 3888/4885PDE3A 3974/4885MEN1 160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.