Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.35 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4812628 | 0.80 | GPR119 (0.42) | NPC1RAB9AKDM4EPKMUSP30 | |
| SCHEMBL7121817 | 0.73 | HSD17B3 (0.41) | LIMK2 | |
| SCHEMBL7429016 | 0.71 | NPC1 (0.35) | NPC1RAB9AKDM4EMEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL7433732 | 0.70 | SLC6A2 (0.34) | — | |
| SCHEMBL7430527 | 0.70 | PDK1 (0.34) | NPC1RAB9AKDM4EMEN1KMT2A | |
| SCHEMBL7430920 | 0.69 | PDK1 (0.34) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL5210913 | 0.68 | NPC1 (0.39) | NPC1RAB9AKDM4E | |
| SCHEMBL5210889 | 0.67 | NPC1 (0.40) | NPC1RAB9AKDM4E | |
| SCHEMBL5216930 | 0.67 | RAB9A (0.37) | NPC1RAB9AKDM4E | |
| SCHEMBL5210074 | 0.67 | RXRB (0.38) | NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294691-A1 | SERINE PROTEASE INHIBITORS | Tularik Limited (GB) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001096305-A1 | SERINE PROTEASE INHIBITORS | TULARIK LIMITED (GB) | 2001-12-20 | — | — | WO | disclosed |