Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL7269785 | 0.86 | ALDH1A1 (0.45) | KCNN4ALDH1A1MEN1KMT2AKDM4E | |
| Dimethylamine SCHEMBL8511811 | 0.84 | KCNN4 (0.43) | KCNN4ALDH1A1MAOAMAOBMEN1 | |
| SCHEMBL362964 | 0.84 | TSHR (0.43) | KCNN4ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL15171994 | 0.78 | ESR1 (0.37) | KCNN4ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL4796677 | 0.77 | MEN1 (0.44) | ALDH1A1MEN1KMT2ALMNAHTT | |
| SCHEMBL30056216 | 0.77 | LMNA (0.41) | ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL16313233 | 0.76 | TSHR (0.45) | KCNN4ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL1812486 | 0.76 | KIF11 (0.49) | ALDH1A1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL1793818 | 0.76 | NR1H2 (0.48) | ALDH1A1MEN1KMT2AKDM4EL3MBTL1 | |
| SCHEMBL11571566 | 0.75 | KIF11 (0.47) | ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608215-B2 | Photochromic ophthalmic or sun protection lenses, glass paneling | VISION-EASE LENS, INC. | 2003-08-19 | — | — | US | disclosed |
| US-20030092918-A1 | Oxygen-containing heterocyclic fused naphthopyrans | VISION-EASE LENS, INC. | 2003-05-15 | — | — | US | disclosed |
| WO-2003025638-A1 | OXYGEN-CONTAINING HETEROCYCLIC FUSED NAPHTHOPYRANS | VISION-EASE LENS, INC. (US) | 2003-03-27 | — | — | WO | disclosed |
| WO-1999031081-A1 | PH SENSITIVE PHOTOCHROMIC DYES | JAMES ROBINSON LIMITED (GB) | 1999-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030092918-A1 | Oxygen-containing heterocyclic fused naphthopyrans | NQO1, NFE2L2, NDUFV2 | KCNN4 2122/4885ALDH1A1 202/4885MAOA 501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.