Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL975 | 0.95 | — | — | |
| Tromethamine SCHEMBL3696191 | 0.95 | — | — | |
| Tromethamine SCHEMBL17484 | 0.95 | MEN1 (1.00) | — | |
| Tromethamine SCHEMBL445853 | 0.91 | MEN1 (0.91) | — | |
| Tromethamine SCHEMBL8379571 | 0.91 | — | — | |
| Tromethamine SCHEMBL7068977 | 0.91 | — | — | |
| Tromethamine SCHEMBL2035496 | 0.91 | — | — | |
| Tromethamine SCHEMBL2263148 | 0.91 | MEN1 (0.91) | — | |
| Tromethamine SCHEMBL6063594 | 0.91 | — | — | |
| Tromethamine SCHEMBL9298764 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6384162-B1 | COORDINATION CATALYST OF VANADIUM TRIS DIKETATE, HALOGENATED ORGANOALUMINUM, AND CHLORINATED ESTER ACTIVATOR; ETHYLENE PROPYLENE TETRAPOLYMERS WITH TWO DIOLEFIN MONOMERS SUCH AS 5-ETHYLIDENE-2-NORBORNENE AND 5-VINYLIDINE-2-NORBORNENE | BAYER AKTIENGESELLSCHAFT (DE) | 2002-05-07 | — | — | US | claimed |
| CN-112292477-A | Cyclic deposition methods for forming metal-containing materials and films and structures containing metal-containing materials | ASM IP私人控股有限公司 | 2021-01-29 | — | — | CN | disclosed |
| CN-112292478-A | Cyclic deposition methods for forming metal-containing materials and films and structures containing metal-containing materials | ASM IP私人控股有限公司 | 2021-01-29 | — | — | CN | disclosed |
| CN-111825570-A | Forming material, forming method and novel compound | 气相成长株式会社 | 2020-10-27 | — | — | CN | disclosed |
| US-20200331944-A1 | COMPOUND | GAS-PHASE GROWTH LTD. (JP) | 2020-10-22 | — | — | US | disclosed |
| JP-2003049269-A | METHOD FOR PRODUCING VANADIUM-CONTAINING OXIDE THIN FILM BY VAPOR-PHASE GROWTH METHOD USING VANADIUM TRIS (β-DIKETONATE) AND RAW MATERIAL SOLUTION | KOJUNDO CHEM LAB CO LTD | 2003-02-21 | — | — | JP | disclosed |