Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.61 |
| ▸ | NAMPT | P43490 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5665029 | 0.89 | EPHX2 (0.76) | ROCK2ROCK1KMT2AMEN1TSHR | |
| SCHEMBL18825628 | 0.88 | RORC (0.63) | ROCK2ROCK1KMT2AMEN1TSHR | |
| SCHEMBL13167592 | 0.83 | NAMPT (0.82) | ROCK2ROCK1KMT2AMEN1LMNA | |
| SCHEMBL11161284 | 0.82 | ROCK2 (0.66) | ROCK2ROCK1KMT2AMEN1TSHR | |
| SCHEMBL29362556 | 0.81 | ROCK2 (0.73) | ROCK2ROCK1KMT2AMEN1LMNA | |
| SCHEMBL9031269 | 0.81 | ROCK2 (0.73) | ROCK2ROCK1KMT2AMEN1LMNA | |
| SCHEMBL6122991 | 0.80 | ABL1 (0.76) | ROCK2ROCK1KMT2ARAB9ANPC1 | |
| SCHEMBL12977899 | 0.80 | RAB9A (0.67) | LMNAHIF1AEPHX2NAMPTRAB9A | |
| SCHEMBL5384036 | 0.79 | ROCK2 (0.76) | ROCK2ROCK1KMT2AMEN1LMNA | |
| Nicotinanilide SCHEMBL352439 | 0.79 | LMNA (0.83) | ROCK2ROCK1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358184-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | Amgen Inc. (US) | 2003-11-05 | — | — | EP | claimed |
| WO-2002066470-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2002-08-29 | — | — | WO | claimed |
| EP-1358184-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | Amgen Inc. (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002066470-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2002-08-29 | — | — | WO | disclosed |