Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 7/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 7/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | RARB | P10826 | 2/20 | 0.31 |
| ▸ | RARA | P10276 | 1/20 | 0.31 |
| ▸ | RARG | P13631 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL222939 | 0.79 | LPL (0.55) | LPLLIPGCA1CA2TRPV1 | |
| SCHEMBL712768 | 0.79 | MC4R (0.31) | LIPG | |
| SCHEMBL712766 | 0.79 | MC4R (0.31) | LIPG | |
| SCHEMBL9926820 | 0.78 | TAAR1 (0.32) | LPLLIPGTAAR1 | |
| SCHEMBL9926824 | 0.73 | — | — | |
| SCHEMBL25824860 | 0.70 | TAAR1 (0.45) | KCNH2TMEM97SIGMAR1TAAR1 | |
| SCHEMBL1979236 | 0.70 | CHRNB2 (0.38) | TAAR1 | |
| SCHEMBL9474140 | 0.70 | ESR1 (0.46) | CA1CA2KCNH2TMEM97SIGMAR1 | |
| SCHEMBL9474134 | 0.70 | ESR1 (0.46) | CA1CA2KCNH2TMEM97SIGMAR1 | |
| SCHEMBL11527913 | 0.68 | MMP12 (0.49) | KCNH2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8350100-B2 | Process for the preparation of ring compounds | MERCK PATENT GMBH (DE) | 2013-01-08 | — | — | US | disclosed |
| US-20120149943-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | MERCK GMBH (DE) | 2012-06-14 | — | — | US | disclosed |
| US-8124817-B2 | Process for the preparation of ring compounds | MERCK PATENT GMBH (DE) | 2012-02-28 | — | — | US | disclosed |
| US-20110034738-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | PAULUTH DETLEF | 2011-02-10 | — | — | US | disclosed |
| US-7842845-B2 | Process for the preparation of ring compounds | MERCK GMBH (DE) | 2010-11-30 | — | — | US | disclosed |
| US-7786332-B2 | Process for the preparation of ring compounds | MERCK PATENT GMBH (DE) | 2010-08-31 | — | — | US | disclosed |
| US-20090318727-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | PAULUTH DETLEF | 2009-12-24 | — | — | US | disclosed |
| US-20080319235-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | PAULUTH DETLEF | 2008-12-25 | — | — | US | disclosed |
| US-7411100-B2 | Process for the preparation of ring compounds | MERCK GMBH (DE) | 2008-08-12 | — | — | US | disclosed |
| US-7183447-B2 | Process for the preparation of ring compounds | MERCK PATENT GMBH (DE) | 2007-02-27 | — | — | US | disclosed |
| US-20060216754-A1 | Process for the preparation of ring compounds | PAULUTH DETLEF | 2006-09-28 | — | — | US | disclosed |
| US-20040006235-A1 | Process for the preparation of ring compounds | MERCK PATENT GMBH (DE) | 2004-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006235-A1 | Process for the preparation of ring compounds | NBAS, HDHD5, DBF4 | LPL 3496/4885LIPG 2737/4885CA1 1207/4885 |
| US-20120149943-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | NBAS, HDHD5, DBF4 | LPL 3503/4885LIPG 2746/4885CA1 1203/4885 |
| US-20080319235-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | NBAS, HDHD5, DBF4 | LPL 3496/4885LIPG 2737/4885CA1 1207/4885 |
| US-20110034738-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | NBAS, HDHD5, DBF4 | LPL 3496/4885LIPG 2737/4885CA1 1207/4885 |
| US-20090318727-A1 | PROCESS FOR THE PREPARATION OF RING COMPOUNDS | NBAS, HDHD5, DBF4 | LPL 3496/4885LIPG 2737/4885CA1 1207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.