Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | GRK5 | P34947 | 1/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | PRKX | P51817 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7125049 | 1.00 | CYP2C19 (0.52) | CYP2C19HIF1AESR2ALDH1A1ESR1 | |
| SCHEMBL3228621 | 1.00 | CYP2C19 (0.52) | CYP2C19HIF1AESR2ALDH1A1ESR1 | |
| SCHEMBL3190736 | 0.83 | CYP2C19 (0.48) | CYP2C19HIF1AESR2ALDH1A1ESR1 | |
| SCHEMBL75391 | 0.82 | ALDH1A1 (0.72) | CYP2C19HIF1AESR2ALDH1A1ESR1 | |
| SCHEMBL1682512 | 0.82 | HIF1A (0.53) | CYP2C19HIF1AESR2ALDH1A1ESR1 | |
| SCHEMBL25332888 | 0.81 | CYP2C19 (0.69) | CYP2C19HIF1AESR2ALDH1A1MAPT | |
| SCHEMBL3291465 | 0.81 | CYP2C19 (0.69) | CYP2C19HIF1AESR2ALDH1A1MAPT | |
| SCHEMBL1202058 | 0.81 | CYP2C19 (0.69) | CYP2C19HIF1AESR2ALDH1A1MAPT | |
| SCHEMBL11837442 | 0.80 | CYP2C9 (0.54) | HIF1AESR2ALDH1A1ESR1CYP3A4 | |
| SCHEMBL11830813 | 0.80 | POLB (0.49) | CYP2C19ESR2ALDH1A1ESR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030096019-A1 | Methods of using norfluoxetine | SEPRACOR INC. | 2003-05-22 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030096019-A1 | Methods of using norfluoxetine | NGF, TPH2, ALOX5 | CYP2C19 78/4885HIF1A 2735/4885ESR2 2408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.