Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6679197 | 0.89 | ALDH1A1 (0.49) | ALDH1A1LMNATRPA1MEN1KMT2A | |
| SCHEMBL6789742 | 0.86 | LMNA (0.40) | ALDH1A1LMNATRPA1MEN1KMT2A | |
| SCHEMBL6678209 | 0.85 | ALDH1A1 (0.38) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| SCHEMBL6683259 | 0.84 | ALDH1A1 (0.35) | ALDH1A1KMT2ATSHRNPSR1PKM | |
| SCHEMBL7123002 | 0.82 | ALDH1A1 (0.38) | ALDH1A1LMNATRPA1MEN1KMT2A | |
| SCHEMBL7130471 | 0.80 | ALDH1A1 (0.37) | ALDH1A1LMNATRPA1MEN1KMT2A | |
| SCHEMBL6679503 | 0.80 | TRPA1 (0.42) | ALDH1A1LMNATRPA1MEN1KMT2A | |
| SCHEMBL6684431 | 0.76 | KMT2A (0.49) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| SCHEMBL6789030 | 0.73 | L3MBTL1 (0.42) | ALDH1A1LMNATRPA1MEN1KMT2A | |
| SCHEMBL7127312 | 0.71 | ALDH1A1 (0.49) | ALDH1A1LMNATRPA1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224951-A1 | 5,6-Fused uracil derivatives as matrix metalloproteinase inhibitors | ROARK WILLIAM HOWARD (US) | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224951-A1 | 5,6-Fused uracil derivatives as matrix metalloproteinase inhibitors | MMP9, MMP13, MMP25 | ALDH1A1 812/4885LMNA 3842/4885TRPA1 4726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.