Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 5/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7136320 | 0.86 | ADAMTS5 (0.54) | ADAMTS5NTRK1MEN1NPC1RAB9A | |
| SCHEMBL7134023 | 0.86 | ADAMTS5 (0.43) | ADAMTS5KIF11NTRK1CISD1NR1H4 | |
| SCHEMBL7130522 | 0.86 | ADAMTS5 (0.51) | ADAMTS5NTRK1MEN1NPC1RAB9A | |
| SCHEMBL7133306 | 0.85 | ADAMTS5 (0.50) | ADAMTS5NTRK1PIM1PIM2MEN1 | |
| SCHEMBL7134866 | 0.83 | LRRK2 (0.50) | PIM1PIM2MEN1NPC1RAB9A | |
| SCHEMBL7137562 | 0.83 | ADAMTS5 (0.52) | ADAMTS5NTRK1MEN1NPC1RAB9A | |
| SCHEMBL7136994 | 0.79 | MAOA (0.44) | PIM1PIM2MEN1KMT2ARET | |
| SCHEMBL7136206 | 0.78 | RET (0.50) | NTRK1KMT2APOLBAKR1B1RET | |
| SCHEMBL7134020 | 0.78 | LRRK2 (0.49) | PIM1PIM2RET | |
| SCHEMBL7135594 | 0.77 | MMP13 (0.50) | ADAMTS5NTRK1NR1H4MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |