Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 7/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139969 | 0.86 | KDM4E (0.51) | MAPK1ROCK2KITHTTMMP3 | |
| SCHEMBL4690818 | 0.81 | ADORA3 (0.48) | MAPK1ADORA3ROCK2MMP3ROCK1 | |
| SCHEMBL7137817 | 0.76 | HTT (0.51) | MAPK1HTTKDM4EPOLB | |
| SCHEMBL1709275 | 0.76 | CFD (0.57) | ADORA3ROCK2HTTMMP3ROCK1 | |
| SCHEMBL7625239 | 0.72 | RAB9A (0.55) | HTTKDM4EKDR | |
| SCHEMBL7143265 | 0.71 | RAB9A (0.60) | KITHTTPOLBKDR | |
| SCHEMBL4849766 | 0.70 | ROCK2 (0.52) | ADORA3ROCK2ROCK1KDM4EGSK3B | |
| SCHEMBL13373356 | 0.70 | ROCK2 (0.74) | ROCK2HTTROCK1 | |
| SCHEMBL13893341 | 0.70 | KDM4E (0.51) | ROCK2HTTMMP3ROCK1KDM4E | |
| SCHEMBL4690820 | 0.69 | LMNA (0.66) | MAPK1ADORA3ROCK2MMP3ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |