Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | THRB | P10828 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | MAPT | P10636 | 9/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1855131 | 0.99 | MEN1 (0.53) | MEN1KMT2ATHRBALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7134410 | 0.97 | MEN1 (0.52) | MEN1KMT2ATHRBALDH1A1MAPT | |
| SCHEMBL3972410 | 0.97 | MEN1 (0.54) | MEN1KMT2ATHRBALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL9304960 | 0.96 | MEN1 (0.51) | MEN1KMT2ATHRBALDH1A1MAPT | |
| SCHEMBL10626585 | 0.92 | MEN1 (0.50) | MEN1KMT2ATHRBALDH1A1MAPT | |
| SCHEMBL11873266 | 0.92 | MEN1 (0.50) | MEN1KMT2ATHRBALDH1A1MAPT | |
| SCHEMBL131153 | 0.92 | MEN1 (0.50) | MEN1KMT2ATHRBALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7794311 | 0.87 | MEN1 (0.50) | MEN1KMT2ATHRBALDH1A1MAPT | |
| SCHEMBL28916467 | 0.82 | MAPT (0.47) | MEN1KMT2ATHRBALDH1A1MAPT | |
| SCHEMBL10511000 | 0.81 | SIRT6 (0.45) | MEN1KMT2ATHRBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6528652-B1 | Thiazole ester and diazonium salt | CHRONIMED | 2003-03-04 | — | — | US | disclosed |
| US-6503725-B2 | Compound for use in the diagnosis and treatment of urogential and kidney disorders | HYPOGUARD AMERICA LIMITED (GB) | 2003-01-07 | — | — | US | disclosed |
| US-20020120151-A1 | Composition and device for detecting leukocytes in urine | HYPOGUARD AMERICA LIMITED (GB) | 2002-08-29 | — | — | US | disclosed |
| US-20020058301-A1 | Composition and device for detecting leukocytes in urine | HYPOGUARD AMERICA LIMITED (GB) | 2002-05-16 | — | — | US | disclosed |
| US-6348324-B1 | THIAZOLE ESTERS WHICH ARE HYDROLYZED UPON EXPOSURE TO LEUKOCYTES IN URINE AND CAN THEN REACT WITH DIAZONIUM SALTS TO PRODUCE AZO DYES | HYPOGUARD AMERICA LIMITED (GB) | 2002-02-19 | — | — | US | disclosed |
| EP-1163360-A2 | COMPOSITION AND DEVICE FOR DETECTING LEUKOCYTES IN URINE | Hypoguard America Limited (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000043535-A2 | COMPOSITION AND DEVICE FOR DETECTING LEUKOCYTES IN URINE | HYPOGUARD AMERICA LIMITED (US) | 2000-07-27 | — | — | WO | disclosed |
| US-5750359-A | Composition for detecting leucocyte and proteinase in urine and its measuring device | CHUNG-DO PHARMACEUTICAL CO., LTD. (KR) | 1998-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020120151-A1 | Composition and device for detecting leukocytes in urine | CCR1, CCR3, NPPA | MEN1 3913/4885KMT2A 3183/4885THRB 204/4885 |
| US-20020058301-A1 | Composition and device for detecting leukocytes in urine | NPPA, AADAT, DNPEP | MEN1 3806/4885KMT2A 2374/4885THRB 292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.