Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6850921 | 0.91 | SPHK1 (0.54) | SPHK1CYP2D6GMNNLMNAPOLB | |
| SCHEMBL29457699 | 0.84 | LMNA (0.42) | SPHK1LMNA | |
| SCHEMBL29457698 | 0.84 | LMNA (0.42) | SPHK1LMNA | |
| SCHEMBL26633394 | 0.79 | SPHK1 (0.47) | SPHK1CYP2D6GMNNLMNAPOLB | |
| SCHEMBL26633398 | 0.79 | SPHK1 (0.47) | SPHK1CYP2D6GMNNLMNAPOLB | |
| SCHEMBL1234977 | 0.78 | SPHK1 (0.52) | SPHK1CYP2D6CA2GMNNLMNA | |
| SCHEMBL7708644 | 0.78 | SPHK1 (0.52) | SPHK1CYP2D6CA2GMNNLMNA | |
| SCHEMBL30575899 | 0.78 | SPHK1 (0.52) | SPHK1CYP2D6CA2GMNNLMNA | |
| SCHEMBL600713 | 0.78 | SPHK1 (0.52) | SPHK1CYP2D6CA2GMNNLMNA | |
| SCHEMBL27881377 | 0.78 | SPHK1 (0.52) | SPHK1CYP2D6CA2GMNNLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9908970-B2 | Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method | NEKTAR THERAPEUTICS (US) | 2018-03-06 | — | — | US | disclosed |
| US-20170121459-A1 | POLYMERIC ALPHA-HYDROXY ALDEHYDE AND KETONE REAGENTS AND CONJUGATION METHOD | NEKTAR THERAPEUTICS | 2017-05-04 | — | — | US | disclosed |
| US-9579392-B2 | Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method | NEKTAR THERAPEUTICS (US) | 2017-02-28 | — | — | US | disclosed |
| US-20160144046-A1 | POLYMERIC ALPHA-HYDROXY ALDEHYDE AND KETONE REAGENTS AND CONJUGATION METHOD | NEKTAR THERAPEUTICS | 2016-05-26 | — | — | US | disclosed |
| US-9228053-B2 | Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method | NEKTAR THERAPEUTICS (US) | 2016-01-05 | — | — | US | disclosed |
| US-20130280783-A1 | POLYMERIC ALPHA-HYDROXY ALDEHYDE AND KETONE REAGENTS AND CONJUGATION METHOD | NEKTAR THERAPEUTICS | 2013-10-24 | — | — | US | disclosed |
| EP-2170804-B1 | Method of producing 2-phenoxyacetals and the corresponding 2-phenoxy-carbaldehydes therefrom | SALTIGO GMBH (DE) | 2013-08-28 | — | — | EP | disclosed |
| EP-2170804-B1 | Method of producing 2-phenoxyacetals and the corresponding 2-phenoxy-carbaldehydes therefrom | SALTIGO GMBH (DE) | 2013-08-28 | — | — | EP | disclosed |
| US-8492503-B2 | Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method | NEKTAR THERAPEUTICS (US) | 2013-07-23 | — | — | US | disclosed |
| US-8143455-B2 | Process for preparing 2-hydroxyacetals and the corresponding 2-hydroxyalkanals | SALTIGO GMBH (US) | 2012-03-27 | — | — | US | disclosed |
| US-20110230618-A1 | Polymeric Alpha-Hydroxy Aldehyde and Ketone Reagents and Conjugation Method | NEKTAR THERAPEUTICS (US) | 2011-09-22 | — | — | US | disclosed |
| US-20100286449-A1 | METHOD OF PRODUCING 2-PHENOXYACETALS AND THE CORRESPONDING 2-PHENOXY-CARBALDEHYDES THEREFROM | SALTIGO GMBH (DE) | 2010-11-11 | — | — | US | disclosed |
| US-20100286449-A1 | METHOD OF PRODUCING 2-PHENOXYACETALS AND THE CORRESPONDING 2-PHENOXY-CARBALDEHYDES THEREFROM | SALTIGO GMBH (DE) | 2010-11-11 | — | — | US | disclosed |
| US-20100286449-A1 | METHOD OF PRODUCING 2-PHENOXYACETALS AND THE CORRESPONDING 2-PHENOXY-CARBALDEHYDES THEREFROM | SALTIGO GMBH (DE) | 2010-11-11 | — | — | US | disclosed |
| US-20100280276-A1 | PROCESS FOR PREPARING 2-HYDROXYACETALS AND THE CORRESPONDING 2-HYDROXYALKANALS | SALTIGO GMBH (DE) | 2010-11-04 | — | — | US | disclosed |
| US-20100280276-A1 | PROCESS FOR PREPARING 2-HYDROXYACETALS AND THE CORRESPONDING 2-HYDROXYALKANALS | SALTIGO GMBH (DE) | 2010-11-04 | — | — | US | disclosed |
| EP-2170804-A1 | METHOD OF PRODUCING 2-PHENOXYACETALS AND THE CORRESPONDING 2-PHENOXY-CARBALDEHYDES THEREFROM | Saltigo GmbH (DE) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009000651-A1 | METHOD OF PRODUCING 2-PHENOXYACETALS AND THE CORRESPONDING 2-PHENOXY-CARBALDEHYDES THEREFROM | SALTIGO GMBH (DE) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009000651-A1 | METHOD OF PRODUCING 2-PHENOXYACETALS AND THE CORRESPONDING 2-PHENOXY-CARBALDEHYDES THEREFROM | SALTIGO GMBH (DE) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009000649-A1 | PROCESS FOR PREPARING 2-HYDROXYACETALS AND THE CORRESPONDING 2-HYDROXYALKANALS | SALTIGO GMBH (DE) | 2008-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280276-A1 | PROCESS FOR PREPARING 2-HYDROXYACETALS AND THE CORRESPONDING 2-HYDROXYALKANALS | HAO2, HAO1, AKR1C3 | SPHK1 2668/4885CYP2D6 17/4885CA2 370/4885 |
| US-20100286449-A1 | METHOD OF PRODUCING 2-PHENOXYACETALS AND THE CORRESPONDING 2-PHENOXY-CARBALDEHYDES THEREFROM | CYP2B6, CYP2A6, UGT1A6 | SPHK1 3744/4885CYP2D6 4/4885CA2 754/4885 |
| US-20160144046-A1 | POLYMERIC ALPHA-HYDROXY ALDEHYDE AND KETONE REAGENTS AND CONJUGATION METHOD | ASPH, ALDH1A1, ADH1C | SPHK1 1269/4885CYP2D6 1275/4885CA2 2753/4885 |
| US-20130280783-A1 | POLYMERIC ALPHA-HYDROXY ALDEHYDE AND KETONE REAGENTS AND CONJUGATION METHOD | ASPH, ALDH1A1, ADH1C | SPHK1 1269/4885CYP2D6 1275/4885CA2 2753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.