Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.40 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | ACP1 | P24666 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2174830 | 0.71 | PRKDC (0.62) | ALOX15HSD17B10PIK3CDPIK3CAPIK3CB | |
| SCHEMBL5054794 | 0.71 | PRKDC (0.54) | ALOX15ERN1PRKDCALDH1A1MAPT | |
| SCHEMBL6997120 | 0.70 | ALDH1A1 (0.48) | ALDH3A1ALDH1A3CYP2C9ALOX15HSD17B10 | |
| SCHEMBL1829471 | 0.70 | ERN1 (0.34) | HSD17B10ERN1MAPTKMT2AMEN1 | |
| SCHEMBL25370544 | 0.67 | LGMN (0.54) | ALOX15PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL6997718 | 0.67 | GPR55 (0.49) | ALDH3A1ALDH1A3CYP2C9ALOX15HSD17B10 | |
| SCHEMBL1701348 | 0.67 | PIK3CD (0.51) | ALOX15HSD17B10PIK3CDPIK3CAPIK3CB | |
| SCHEMBL25371978 | 0.65 | SMPD3 (0.41) | CYP2C9HSD17B10PIK3CAALDH1A1MAPT | |
| SCHEMBL1832013 | 0.64 | ERN1 (0.46) | HSD17B10ERN1ALDH1A1MAPTKMT2A | |
| SCHEMBL250808 | 0.64 | NOTUM (0.49) | ALDH3A1ALDH1A3CYP2C9PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351946-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002020500-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |