Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
| ▸ | BCL6 | P41182 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989674 | 0.90 | CYP1A2 (0.50) | LMNAMAPKAPK2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6988180 | 0.80 | NAMPT (0.51) | LMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6981925 | 0.79 | NAMPT (0.50) | LMNACYP1A2CYP3A4CYP2C9MAPT | |
| SCHEMBL6988688 | 0.78 | ABCC9 (0.41) | LMNAMAPKAPK2TBXA2RTBXAS1LRRK2 | |
| SCHEMBL6990458 | 0.78 | CSF1R (0.44) | LMNAMAPKAPK2ALDH1A1MAPTTBXA2R | |
| SCHEMBL6988947 | 0.78 | PLK1 (0.44) | LMNAMAPKAPK2GAACYP1A2CYP3A4 | |
| SCHEMBL6988714 | 0.77 | SIRT2 (0.43) | MAPKAPK2ALDH1A1TBXA2RTBXAS1ROCK2 | |
| SCHEMBL6987131 | 0.77 | GRM5 (0.44) | LMNACYP1A2CYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL6989487 | 0.77 | ALDH1A1 (0.49) | LMNAGAAALDH1A1SMN1; SMN2LRRK2 | |
| SCHEMBL6986333 | 0.77 | MEN1 (0.48) | GAAALDH1A1MAPTSMN1; SMN2TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | claimed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | claimed |