Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | FOS | P01100 | 1/20 | 0.41 |
| ▸ | JUN | P05412 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5091586 | 0.93 | FOS (0.46) | PDE4APDE4DFOSJUNNFKB1 | |
| SCHEMBL5093408 | 0.88 | ADORA3 (0.47) | MAPTALDH1A1ADORA3ADORA2AADORA1 | |
| SCHEMBL7853285 | 0.88 | FOS (0.44) | FOSJUNNFKB1NFKB2RELA | |
| SCHEMBL5092765 | 0.82 | FOS (0.47) | PDE4APDE4DFOSJUNNFKB1 | |
| SCHEMBL27570893 | 0.81 | ALDH1A1 (0.46) | PDE4APDE4DMAPTALDH1A1LMNA | |
| SCHEMBL5098932 | 0.77 | FOS (0.47) | PDE4APDE4DFOSJUNNFKB1 | |
| SCHEMBL27559848 | 0.76 | PKM (0.44) | MAPTALDH1A1ADORA3ADORA2AADORA1 | |
| SCHEMBL5089195 | 0.76 | ALDH1A1 (0.48) | FOSJUNNFKB1NFKB2RELA | |
| SCHEMBL5089370 | 0.75 | MAPT (0.44) | MAPTALDH1A1ADORA3ADORA2AADORA1 | |
| SCHEMBL5093430 | 0.75 | RAB9A (0.49) | MAPTALDH1A1LMNAMAPK1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |