Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.34 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
| ▸ | KHK | P50053 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 2/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | REN | P00797 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6749057 | 0.96 | HSD11B1 (0.44) | HSD11B1ICAM1VCAM1KHKALDH1A1 | |
| SCHEMBL19000148 | 0.81 | HSD11B1 (0.52) | HSD11B1ALDH1A1TSHR | |
| SCHEMBL6747271 | 0.79 | ITGB3 (0.34) | ALDH1A1SMN1; SMN2ACEREN | |
| SCHEMBL3754325 | 0.78 | HSD11B1 (0.56) | HSD11B1KDM4ETSHRHSD17B10 | |
| SCHEMBL20417970 | 0.73 | ARG1 (0.31) | SMN1; SMN2 | |
| SCHEMBL19051289 | 0.72 | HSD11B1 (0.40) | HSD11B1KHKTSHR | |
| SCHEMBL20652118 | 0.72 | HSD11B1 (0.39) | HSD11B1ICAM1VCAM1ACEHSD17B10 | |
| SCHEMBL7142983 | 0.72 | HRH3 (0.33) | — | |
| SCHEMBL7142985 | 0.72 | HRH3 (0.33) | — | |
| SCHEMBL8319934 | 0.71 | ALDH1A1 (0.37) | HSD11B1ALDH1A1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518423-B1 | These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and | EISAI CO., LTD. (JP) | 2003-02-11 | — | — | US | disclosed |
| EP-0934941-A1 | BENZOPIPERIDINE DERIVATIVES | Eisai Co., Ltd. (JP) | 1999-08-11 | — | — | EP | disclosed |