Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6752121 | 0.86 | ICAM1 (0.35) | ALDH1A1POLBTDP1ICAM1KDM4E | |
| SCHEMBL6749892 | 0.70 | ALDH1A1 (0.36) | ALDH1A1TDP1KDM4ETSHR | |
| SCHEMBL8522768 | 0.67 | ICAM1 (0.36) | ALDH1A1ICAM1KDM4ESMN1; SMN2 | |
| SCHEMBL6749346 | 0.63 | HDAC6 (0.37) | — | |
| SCHEMBL8322460 | 0.63 | ICAM1 (0.40) | ICAM1MEN1KMT2A | |
| SCHEMBL6750490 | 0.63 | HDAC6 (0.35) | KMT2A | |
| SCHEMBL6747171 | 0.62 | PABPC1 (0.41) | ALDH1A1POLBKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL6749436 | 0.61 | UBE2M (0.34) | ICAM1 | |
| SCHEMBL7149128 | 0.61 | HDAC6 (0.38) | POLBTDP1ICAM1SMN1; SMN2MEN1 | |
| SCHEMBL6747276 | 0.61 | HDAC6 (0.42) | ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518423-B1 | These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and | EISAI CO., LTD. (JP) | 2003-02-11 | — | — | US | disclosed |
| EP-0934941-A1 | BENZOPIPERIDINE DERIVATIVES | Eisai Co., Ltd. (JP) | 1999-08-11 | — | — | EP | disclosed |